Version 5.4
Mus musculus Gene: Itga5
Summary
InnateDB Gene IDBG-189590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itga5
Gene Name integrin alpha 5 (fibronectin receptor alpha)
Synonyms Cd49e; Fnra; VLA5
Species Mus musculus
Ensembl Gene ENSMUSG00000000555
Encoded Proteins
IDBP-189592
integrin alpha 5 (fibronectin receptor alpha)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161638:
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:103344289-103366763
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000023128 ENSMUSP00000023128
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0007044 cell-substrate junction assembly
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007613 memory
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030335 positive regulation of cell migration
GO:0031589 cell-substrate adhesion
GO:0033631 cell-cell adhesion mediated by integrin
GO:0035313 wound healing, spreading of epidermal cells
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:2000811 negative regulation of anoikis
Cellular Component
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0032587 ruffle membrane
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000161638
View Gene Order
ENSBTAG00000013745
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_204211
Fibronectin matrix formation pathway
REACT_198996
Elastic fibre formation pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_206066
Extracellular matrix organization pathway
REACT_261444
Axon guidance pathway
REACT_216309
Integrin cell surface interactions pathway
REACT_215461
Signal transduction by L1 pathway
REACT_219680
L1CAM interactions pathway
REACT_188576
Developmental Biology pathway
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04640
Hematopoietic cell lineage pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04510
Focal adhesion pathway
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu04145
Phagosome pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_150366
Elastic fibre formation pathway
REACT_160131
Fibronectin matrix formation pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_118779
Extracellular matrix organization pathway
REACT_18266
Axon guidance pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04640
Hematopoietic cell lineage pathway
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
hsa04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_cs_pathway
Integrin family cell surface interactions
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
syndecan_4_pathway
Syndecan-4-mediated signaling events
Cross-References
SwissProt P11688
TrEMBL Q3U7M6
UniProt Splice Variant
Entrez Gene 16402
UniGene
RefSeq NM_010577
OMIM
CCDS CCDS27903
HPRD
IMGT
MGI ID MGI:96604
MGI Symbol Itga5
EMBL AC131721 AK152594 X15203 X79003
GenPept BAE31343 CAA33273 CAA55638
RNA Seq Atlas 16402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca