InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AGPAT6

Summary

InnateDB Gene

IDBG-18974.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGPAT6

Gene Name

1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000158669

Encoded Proteins

IDBP-236337

1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)

IDBP-478770

1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)

IDBP-480346

1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)

IDBP-480682

1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:41577187-41625001

Strand

Forward strand

Band

p11.21

Transcripts

ENST00000396987	ENSP00000380184
ENST00000521184
ENST00000520258
ENST00000519853	ENSP00000429477
ENST00000520223	ENSP00000428648
ENST00000521121
ENST00000521806	ENSP00000428630
ENST00000519921
ENST00000523906
ENST00000521349
ENST00000518628

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004366	glycerol-3-phosphate O-acyltransferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0002071	glandular epithelial cell maturation
GO:0006631	fatty acid metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0006641	triglyceride metabolic process
GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0007595	lactation
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0030879	mammary gland development
GO:0040014	regulation of multicellular organism growth
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0046339	diacylglycerol metabolic process
GO:0046474	glycerophospholipid biosynthetic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031545

View Gene Order

ENSBTAG00000005730

Not yet available

Pathways

NETPATH

REACTOME

REACT_120906

Synthesis of PA pathway

REACT_1190

Triglyceride Biosynthesis pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121401

Glycerophospholipid biosynthesis pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

hsa00561

Glycerolipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.355753

RefSeq

NM_178819

HUGO

OMIM

CCDS

CCDS6117

HPRD

12175

IMGT

EMBL

GenPept

RNA Seq Atlas