Mus musculus Gene: Trem1
Summary
InnateDB Gene IDBG-189794.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trem1
Gene Name triggering receptor expressed on myeloid cells 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042265
Encoded Proteins
triggering receptor expressed on myeloid cells 1
triggering receptor expressed on myeloid cells 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Trem1 expression is upregulated following Pseudomonas aeruginosa infection in the cornea and the inhibition of Trem1 reduces the severity of corneal disease. Trem1 acts as an inflammatory amplifier in P. aeruginosa keratitis by modulating TLR signalling and Th1/Th2 responses.
Trem1 expression is induced by vitamin D3 in human bronchial epithelial cells. Activation of TREM1 leads to the induction of human beta defensin 2 and TNF-alpha mRNA in the airway epithelium. (Demonstrated in human)
Trem1 mediates endotoxin tolerance in monocytes through its ability to induce anti- or pro-inflammatory signals depending on its membrane-bound state. (Demonstrated in human)
Trem1 offers protective innate immunity during pneumococcal pneumonia by enhancing the early immune response of alveolar macrophages.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48232768-48246924
Strand Forward strand
Band C
Transcripts
ENSMUST00000048782 ENSMUSP00000038636
ENSMUST00000113251 ENSMUSP00000108877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 0
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0097110 scaffold protein binding
Biological Process
GO:0002374 cytokine secretion involved in immune response
GO:0016477 cell migration
GO:0030593 neutrophil chemotaxis
GO:0042107 cytokine metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0050755 chemokine metabolic process
GO:0070945 neutrophil mediated killing of gram-negative bacterium
GO:0072672 neutrophil extravasation
Cellular Component
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Hemostasis pathway
Cell surface interactions at the vascular wall pathway
Immune System pathway
DAP12 interactions pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.248352
RefSeq NM_021406 XM_006524726 XM_006524727 XM_006524728
OMIM
CCDS CCDS28860
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas