InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndufs3

Summary

InnateDB Gene

IDBG-189838.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufs3

Gene Name

NADH dehydrogenase (ubiquinone) Fe-S protein 3

Synonyms

0610010M09Rik; CI-30kD;

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005510

Encoded Proteins

IDBP-189840

NADH dehydrogenase (ubiquinone) Fe-S protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213619:
This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:90894634-90904827

Strand

Reverse strand

Band

Transcripts

ENSMUST00000005647	ENSMUSP00000005647
ENSMUST00000140248
ENSMUST00000123426
ENSMUST00000139400
ENSMUST00000152059
ENSMUST00000144683

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H

Biological Process

GO:0021762	substantia nigra development
GO:0030308	negative regulation of cell growth
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0031966	mitochondrial membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSG00000213619

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000018483

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

REACTOME

REACT_189162

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_262523

Respiratory electron transport pathway

REACT_188937

Metabolism pathway

REACT_261922

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

KEGG

mmu00190

Oxidative phosphorylation pathway

mmu05010

Alzheimer's disease pathway

mmu05012

Parkinson's disease pathway

mmu05016

Huntington's disease pathway

INOH

PID BIOCARTA

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

REACT_22393

Respiratory electron transport pathway

KEGG

hsa00190

Oxidative phosphorylation pathway

hsa05010

Alzheimer's disease pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

INOH

PID BIOCARTA

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.30113 Mm.467614

RefSeq

NM_026688

OMIM

CCDS

CCDS16418

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas