Mus musculus Gene: Ndufs3
Summary
InnateDB Gene IDBG-189838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndufs3
Gene Name NADH dehydrogenase (ubiquinone) Fe-S protein 3
Synonyms 0610010M09Rik; CI-30kD;
Species Mus musculus
Ensembl Gene ENSMUSG00000005510
Encoded Proteins
NADH dehydrogenase (ubiquinone) Fe-S protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213619:
This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:90894634-90904827
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000005647 ENSMUSP00000005647
ENSMUST00000140248
ENSMUST00000123426
ENSMUST00000139400
ENSMUST00000152059
ENSMUST00000144683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003954 NADH dehydrogenase activity
GO:0005515 protein binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
Biological Process
GO:0021762 substantia nigra development
GO:0030308 negative regulation of cell growth
GO:0055114 oxidation-reduction process
GO:0072593 reactive oxygen species metabolic process
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
The citric acid (TCA) cycle and respiratory electron transport pathway
Respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.30113 Mm.467614
RefSeq NM_026688
OMIM
CCDS CCDS16418
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas