InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ndufs3

Summary

InnateDB Gene

IDBG-189838.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ndufs3

Gene Name

NADH dehydrogenase (ubiquinone) Fe-S protein 3

Synonyms

0610010M09Rik; CI-30kD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005510

Encoded Proteins

IDBP-189840

NADH dehydrogenase (ubiquinone) Fe-S protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213619:
This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:90894634-90904827

Strand

Reverse strand

Band

Transcripts

ENSMUST00000005647	ENSMUSP00000005647
ENSMUST00000140248
ENSMUST00000123426
ENSMUST00000139400
ENSMUST00000152059
ENSMUST00000144683

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003954	NADH dehydrogenase activity
GO:0005515	protein binding
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H

Biological Process

GO:0021762	substantia nigra development
GO:0030308	negative regulation of cell growth
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0031966	mitochondrial membrane