InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Celf1

Summary

InnateDB Gene

IDBG-189931.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Celf1

Gene Name

CUGBP, Elav-like family member 1

Synonyms

1600010O03Rik; AA407467; Brunol2; CUG-BP; CUG-BP1; CUGBP; Cugbp1; D2Wsu101e; HNAB50; NAB50

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005506

Encoded Proteins

IDBP-189933

CUGBP, Elav-like family member 1

IDBP-189935

CUGBP, Elav-like family member 1

IDBP-189937

CUGBP, Elav-like family member 1

IDBP-258070

CUGBP, Elav-like family member 1

IDBP-258072

CUGBP, Elav-like family member 1

IDBP-258074

CUGBP, Elav-like family member 1

IDBP-258076

CUGBP, Elav-like family member 1

IDBP-258078

CUGBP, Elav-like family member 1

IDBP-718403

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149187:
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:90940382-91019497

Strand

Forward strand

Band

Transcripts

ENSMUST00000005643	ENSMUSP00000005643
ENSMUST00000068726	ENSMUSP00000064323
ENSMUST00000068747	ENSMUSP00000070438
ENSMUST00000111455	ENSMUSP00000107082
ENSMUST00000111452	ENSMUSP00000107079
ENSMUST00000111451	ENSMUSP00000107078
ENSMUST00000111449	ENSMUSP00000107076
ENSMUST00000111448	ENSMUSP00000107075
ENSMUST00000150546
ENSMUST00000127580
ENSMUST00000154442
ENSMUST00000133657
ENSMUST00000127385
ENSMUST00000177642	ENSMUSP00000136109

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0031369	translation initiation factor binding
GO:0042835	BRE binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006376	mRNA splice site selection
GO:0007286	spermatid development
GO:0040018	positive regulation of multicellular organism growth
GO:0043484	regulation of RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000149187

View Gene Order

ENSBTAG00000002520

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.29495 Mm.393354 Mm.409790 Mm.415775 Mm.416039 Mm.490153 Mm.490161

RefSeq

NM_001244891 NM_001244903 NM_017368 NM_198683 XM_006498660 XM_006498661 XM_006498662 XM_006498663 XM_006498664 XM_006498665 XM_006498666 XM_006498668 XM_006498669

OMIM

CCDS

CCDS16420 CCDS16421

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas