Homo sapiens Gene: KLRC2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-18996.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | KLRC2 | ||||||||||||||||||
Gene Name | killer cell lectin-like receptor subfamily C, member 2 | ||||||||||||||||||
Synonyms | CD159c; NKG2-C; NKG2C | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000205809 | ||||||||||||||||||
Encoded Proteins |
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 2
killer cell lectin-like receptor subfamily C, member 2
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 12:10426854-10442300 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p13.2 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
DAP12 signaling pathway
DAP12 interactions pathway
Innate Immune System pathway
Immune System pathway
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KEGG |
Antigen processing and presentation pathway
Natural killer cell mediated cytotoxicity pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 3822 | ||||||||||||||||||
UniGene | Hs.591157 | ||||||||||||||||||
RefSeq | NM_002260 | ||||||||||||||||||
HUGO | HGNC:6375 | ||||||||||||||||||
OMIM | 602891 | ||||||||||||||||||
CCDS | CCDS31745 | ||||||||||||||||||
HPRD | 04202 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 3822 | ||||||||||||||||||