InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cxcr4

Summary

InnateDB Gene

IDBG-189999.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cxcr4

Gene Name

chemokine (C-X-C motif) receptor 4

Synonyms

b2b220Clo; CD184; Cmkar4; LESTR; PB-CKR; PBSF/SDF-1; Sdf1r

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045382

Encoded Proteins

IDBP-190001

chemokine (C-X-C motif) receptor 4

IDBP-535562

chemokine (C-X-C motif) receptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 26026270

Bacterial cell wall glucosaminyl-muramyl dipeptides (GMDPs) bind to the transcription factor Ybx1 to upregulate Nfkb2 and Cxcr4 gene expression.

InnateDB Annotation from Orthologs

Summary

PMID 21094463

[Homo sapiens] CXCR4 is a chemokine receptor that is essential for homing of stem cells and more mature neutrophils to the bone marrow.

PMID 25705792

[Homo sapiens] MIR146A upregulation by CXCR4 antagonist AMD3100 treatment or ZBTB16 silencing, decreases CXCR4 protein expression and prevents HIV-1 infection of leukemic monocytic cell line and CD4(+) T lymphocytes.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121966:
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:128588199-128592293

Strand

Reverse strand

Band

Transcripts

ENSMUST00000052172	ENSMUSP00000053489
ENSMUST00000142893	ENSMUSP00000120153

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	1 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016494	C-X-C chemokine receptor activity
GO:0019955	cytokine binding
GO:0031625	ubiquitin protein ligase binding
GO:0032027	myosin light chain binding
GO:0043130	ubiquitin binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001666	response to hypoxia
GO:0001667	ameboidal cell migration
GO:0001764	neuron migration
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007281	germ cell development
GO:0007399	nervous system development
GO:0007420	brain development
GO:0008045	motor neuron axon guidance
GO:0008354	germ cell migration
GO:0009887	organ morphogenesis
GO:0019722	calcium-mediated signaling
GO:0030334	regulation of cell migration
GO:0042098	T cell proliferation
GO:0042119	neutrophil activation
GO:0043217	myelin maintenance
GO:0045087	innate immune response (InnateDB)
GO:0048699	generation of neurons
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0050920	regulation of chemotaxis
GO:0061351	neural precursor cell proliferation
GO:0070098	chemokine-mediated signaling pathway
GO:0071345	cellular response to cytokine stimulus

Cellular Component

GO:0005764	lysosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030426	growth cone
GO:0031252	cell leading edge
GO:0031410	cytoplasmic vesicle
GO:0070062	extracellular vesicular exosome