Version 5.4
| Homo sapiens Gene: KLRC1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-19034.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | KLRC1 | ||||||||||||||||||
| Gene Name | killer cell lectin-like receptor subfamily C, member 1 | ||||||||||||||||||
| Synonyms | CD159A; NKG2; NKG2A | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000134545 | ||||||||||||||||||
| Encoded Proteins |
killer cell lectin-like receptor subfamily C, member 1
killer cell lectin-like receptor subfamily C, member 1
killer cell lectin-like receptor subfamily C, member 1
killer cell lectin-like receptor subfamily C, member 1
killer cell lectin-like receptor subfamily C, member 1
killer cell lectin-like receptor subfamily C, member 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 12:10442264-10454685 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p13.2 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
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| KEGG |
Antigen processing and presentation pathway
Natural killer cell mediated cytotoxicity pathway
Graft-versus-host disease pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P26715 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 3821 | ||||||||||||||||||
| UniGene | Hs.512576 | ||||||||||||||||||
| RefSeq | NM_213657 NM_002259 NM_007328 NM_213658 XM_005253360 | ||||||||||||||||||
| HUGO | HGNC:6374 | ||||||||||||||||||
| OMIM | 161555 | ||||||||||||||||||
| CCDS | CCDS8626 CCDS8625 | ||||||||||||||||||
| HPRD | 01192 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC068775 AF023840 AF461812 BC012550 BC053840 U54783 U54784 U54785 U54786 X54867 X54868 | ||||||||||||||||||
| GenPept | AAB17133 AAC17488 AAH12550 AAH53840 AAL65234 CAA38649 CAA38650 | ||||||||||||||||||
| RNA Seq Atlas | 3821 | ||||||||||||||||||