Version 5.4
Mus musculus Gene: Ulk1
Summary
InnateDB Gene IDBG-190505.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ulk1
Gene Name unc-51 like kinase 1
Synonyms AU041434; mKIAA0722; Unc51.1
Species Mus musculus
Ensembl Gene ENSMUSG00000029512
Encoded Proteins
IDBP-190507
Unc-51 like kinase 1 (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 25792739
[Homo sapiens] Stimulation of TMEM173-dependent IRF3 activation by ultraviolet radiation is due to apoptotic signalling-dependent disruption of ULK1, a pro-autophagic protein that negatively regulates TMEM173.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177169:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:110784488-110810097
Strand Reverse strand
Band F
Transcripts
ENSMUST00000031490 ENSMUSP00000031490
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0017137 Rab GTPase binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007265 Ras protein signal transduction
GO:0007409 axonogenesis
GO:0008104 protein localization
GO:0009103 lipopolysaccharide biosynthetic process
GO:0010506 regulation of autophagy
GO:0010508 positive regulation of autophagy
GO:0016239 positive regulation of macroautophagy
GO:0021707 cerebellar granule cell differentiation
GO:0021933 radial glia guided migration of cerebellar granule cell
GO:0031102 neuron projection regeneration
GO:0031175 neuron projection development
GO:0031623 receptor internalization
GO:0031669 cellular response to nutrient levels
GO:0042594 response to starvation
GO:0046777 protein autophosphorylation
GO:0048671 negative regulation of collateral sprouting
GO:0048675 axon extension
GO:0051386 regulation of neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0000407 pre-autophagosomal structure
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005829 cytosol
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0034045 pre-autophagosomal structure membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0070969 ULK1-ATG13-FIP200 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000177169
View Gene Order
ENSBTAG00000012987
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04140
Regulation of autophagy pathway
mmu04150
mTOR signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.271898
RefSeq NM_009469 XM_006534851
OMIM
CCDS CCDS19532
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca