Mus musculus Gene: Ptprr
Summary
InnateDB Gene IDBG-191106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptprr
Gene Name protein tyrosine phosphatase, receptor type, R
Synonyms Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR;
Species Mus musculus
Ensembl Gene ENSMUSG00000020151
Encoded Proteins
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
protein tyrosine phosphatase, receptor type, R
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153233:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:116018213-116274932
Strand Forward strand
Band D2
Transcripts
ENSMUST00000063470 ENSMUSP00000064392
ENSMUST00000105271 ENSMUSP00000100907
ENSMUST00000142617
ENSMUST00000148731 ENSMUSP00000120965
ENSMUST00000155606 ENSMUSP00000122259
ENSMUST00000128399 ENSMUSP00000114455
ENSMUST00000124369
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
FSH pathway
REACTOME
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
Erk1/erk2 mapk signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.336316
RefSeq NM_001161837 NM_001161838 NM_001161839 NM_001161840 NM_011217 XM_006513382 XM_006513383
OMIM
CCDS CCDS24182 CCDS48693 CCDS56750
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas