Version 5.4
Mus musculus Gene: Ptprr
Summary
InnateDB Gene IDBG-191106.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ptprr
Gene Name protein tyrosine phosphatase, receptor type, R
Synonyms Gmcp1; mPTP213; PTP-SL; PTPBR7; RPTPRR
Species Mus musculus
Ensembl Gene ENSMUSG00000020151
Encoded Proteins
IDBP-191108
protein tyrosine phosphatase, receptor type, R
IDBP-271233
protein tyrosine phosphatase, receptor type, R
IDBP-542195
protein tyrosine phosphatase, receptor type, R
IDBP-537854
protein tyrosine phosphatase, receptor type, R
IDBP-537543
protein tyrosine phosphatase, receptor type, R
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153233:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:116018213-116274932
Strand Forward strand
Band D2
Transcripts
ENSMUST00000063470 ENSMUSP00000064392
ENSMUST00000105271 ENSMUSP00000100907
ENSMUST00000142617
ENSMUST00000148731 ENSMUSP00000120965
ENSMUST00000155606 ENSMUSP00000122259
ENSMUST00000128399 ENSMUSP00000114455
ENSMUST00000124369
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153233
View Gene Order
ENSBTAG00000015311
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_25
FSH pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q62132
TrEMBL Q5U1U5 Q5U1U6 Q5U1U7 Q5U1U8
UniProt Splice Variant
Entrez Gene 19279
UniGene Mm.336316
RefSeq NM_001161837 NM_001161838 NM_001161839 NM_001161840 NM_011217 XM_006513382 XM_006513383
OMIM
CCDS CCDS24182 CCDS48693 CCDS56750
HPRD
IMGT
MGI ID MGI:109559
MGI Symbol Ptprr
EMBL AF041866 AF129509 BC119230 BC120547 BN000437 BN000438 BN000439 BN000440 BN000442 BN000443 BN000445 BN000446 BN000447 BN000448 BN000449 BN000450 BN000451 BN000452 BN000453 BN000454 CH466539 D31898 Z30313
GenPept AAD09171 AAD29673 AAI19231 AAI20548 BAA06696 CAA82957 CAA82958 CAF06527 CAF06528 CAF06529 CAF06530 CAF21736 CAF21737 CAF21738 CAF21739 EDL21781 EDL21782
RNA Seq Atlas 19279

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca