Homo sapiens Gene: GTF3A
Summary
InnateDB Gene IDBG-19126.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GTF3A
Gene Name general transcription factor IIIA
Synonyms AP2; TFIIIA
Species Homo sapiens
Ensembl Gene ENSG00000122034
Encoded Proteins
general transcription factor IIIA
general transcription factor IIIA
general transcription factor IIIA
general transcription factor IIIA
general transcription factor IIIA
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:27424544-27435823
Strand Forward strand
Band q12.2
Transcripts
ENST00000381140 ENSP00000370532
ENST00000435781 ENSP00000409175
ENST00000419181 ENSP00000389655
ENST00000438571 ENSP00000387806
ENST00000439403 ENSP00000393050
ENST00000466776
ENST00000470606
ENST00000493903
ENST00000482655
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006383 transcription from RNA polymerase III promoter
GO:0009303 rRNA transcription
GO:0010467 gene expression
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
RNA Polymerase III Abortive And Retractive Initiation pathway
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
RNA Polymerase III Transcription Initiation pathway
RNA Polymerase III Transcription pathway
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
Gene Expression pathway
KEGG
INOH
PID NCI
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445977
RefSeq NM_002097
HUGO
OMIM
CCDS CCDS45019
HPRD 02916
IMGT
EMBL
GenPept
RNA Seq Atlas