Version 5.4
Mus musculus Gene: Ctse
Summary
InnateDB Gene IDBG-191348.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctse
Gene Name cathepsin E
Synonyms A430072O03Rik; C920004C08Rik; CatE; CE
Species Mus musculus
Ensembl Gene ENSMUSG00000004552
Encoded Proteins
IDBP-191350
cathepsin E
IDBP-256085
cathepsin E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196188:
The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:131638306-131675505
Strand Forward strand
Band E4
Transcripts
ENSMUST00000073350 ENSMUSP00000073072
ENSMUST00000112411 ENSMUSP00000108030
ENSMUST00000141061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006508 proteolysis
GO:0016540 protein autoprocessing
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005768 endosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000196188
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt P70269
TrEMBL
UniProt Splice Variant
Entrez Gene 13034
UniGene
RefSeq NM_007799
OMIM
CCDS CCDS15271
HPRD
IMGT
MGI ID MGI:107361
MGI Symbol Ctse
EMBL AJ009840 AJ009841 AJ009842 AJ009843 AJ009844 AJ009845 AJ009846 AJ009847 AJ009848 AK143581 AK145875 AK157907 AK165271 BC005432 CH466520 CT010252 X97399 Y10928
GenPept AAH05432 BAE25449 BAE26716 BAE34257 BAE38113 CAA08880 CAA66056 CAA71859 CAJ18460 EDL39705
RNA Seq Atlas 13034

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca