InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Khdrbs1

Summary

InnateDB Gene

IDBG-191571.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Khdrbs1

Gene Name

KH domain containing, RNA binding, signal transduction associated 1

Synonyms

p62; p68; Sam68

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028790

Encoded Proteins

IDBP-191575

KH domain containing, RNA binding, signal transduction associated 1

IDBP-542958

KH domain containing, RNA binding, signal transduction associated 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121774:
This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3\'-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:129703164-129742303

Strand

Reverse strand

Band

D2.2

Transcripts

ENSMUST00000066257	ENSMUSP00000066516
ENSMUST00000129342	ENSMUSP00000115402
ENSMUST00000139936
ENSMUST00000139281

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 130 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	130 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding
GO:0008143	poly(A) binding
GO:0008266	poly(U) RNA binding
GO:0017124	SH3 domain binding
GO:0032403	protein complex binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle
GO:0007166	cell surface receptor signaling pathway
GO:0009967	positive regulation of signal transduction
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045948	positive regulation of translational initiation
GO:0046831	regulation of RNA export from nucleus
GO:0046833	positive regulation of RNA export from nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070618	Grb2-Sos complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000121774

View Gene Order

ENSBTAG00000012497

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

EGFR1 pathway

TCR pathway

Leptin pathway

Prolactin pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.390109 Mm.475304 Mm.8256

RefSeq

NM_011317

OMIM

CCDS

CCDS18703

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas