Version 5.4
Mus musculus Gene: Polr2a
Summary
InnateDB Gene IDBG-191826.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polr2a
Gene Name polymerase (RNA) II (DNA directed) polypeptide A
Synonyms 220kDa; Rpb1; Rpo2-1
Species Mus musculus
Ensembl Gene ENSMUSG00000005198
Encoded Proteins
IDBP-191828
polymerase (RNA) II (DNA directed) polypeptide A
IDBP-191830
polymerase (RNA) II (DNA directed) polypeptide A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181222:
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69733997-69758637
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000058470 ENSMUSP00000050771
ENSMUST00000071213 ENSMUSP00000071200
ENSMUST00000156588
ENSMUST00000151586
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 207 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 47 [view]
Protein-DNA 18 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 207 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181222
View Gene Order
ENSBTAG00000046765
Not yet available
Pathways
NETPATH
REACTOME
REACT_230204
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_203462
Formation of the Early Elongation Complex pathway
REACT_249110
mRNA Splicing pathway
REACT_223654
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_244380
RNA Polymerase II Transcription Initiation pathway
REACT_235610
mRNA Splicing - Minor Pathway pathway
REACT_255334
RNA Polymerase II Promoter Escape pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_226759
Formation of RNA Pol II elongation complex pathway
REACT_232708
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_233397
DNA Repair pathway
REACT_270446
Transcriptional regulation by small RNAs pathway
REACT_226490
RNA Polymerase II Transcription Elongation pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_258231
mRNA Capping pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_224562
Dual incision reaction in TC-NER pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
REACT_257596
RNA Pol II CTD phosphorylation and interaction with CE pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu03020
RNA polymerase pathway
mmu00230
Purine metabolism pathway
mmu05016
Huntington's disease pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt P08775
TrEMBL
UniProt Splice Variant
Entrez Gene 20020
UniGene Mm.16533
RefSeq NM_001291068 NM_009089 XM_006532611
OMIM
CCDS CCDS70217
HPRD
IMGT
MGI ID MGI:98086
MGI Symbol Polr2a
EMBL AL603707 M12130 M14101
GenPept AAA40071 CAI51953
RNA Seq Atlas 20020

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca