InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chrnb1

Summary

InnateDB Gene

IDBG-192004.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrnb1

Gene Name

cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)

Synonyms

Achr-2; Acrb

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041189

Encoded Proteins

IDBP-192006

cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170175:
The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:69784036-69795943

Strand

Reverse strand

Band

Transcripts

ENSMUST00000045971	ENSMUSP00000047270
ENSMUST00000154816
ENSMUST00000129381
ENSMUST00000147791

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0005515	protein binding
GO:0015267	channel activity
GO:0015276	ligand-gated ion channel activity
GO:0015464	acetylcholine receptor activity
GO:0042166	acetylcholine binding

Biological Process

GO:0001941	postsynaptic membrane organization
GO:0003009	skeletal muscle contraction
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006936	muscle contraction
GO:0007165	signal transduction
GO:0007271	synaptic transmission, cholinergic
GO:0007274	neuromuscular synaptic transmission
GO:0034220	ion transmembrane transport
GO:0035095	behavioral response to nicotine
GO:0042391	regulation of membrane potential
GO:0048747	muscle fiber development
GO:0050877	neurological system process
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000170175

View Gene Order

ENSBTAG00000019242

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

P09690

TrEMBL

UniProt Splice Variant

Entrez Gene

11443

UniGene

Mm.86425

RefSeq

NM_009601 XM_006532004

OMIM

CCDS

CCDS24910

HPRD

IMGT

MGI ID

MGI:87890

MGI Symbol

Chrnb1

EMBL

AK087554 AL603707 J04699 M14537

GenPept

AAA37154 AAA37156 BAC39924 CAI51959

RNA Seq Atlas

11443