Version 5.4
Mus musculus Gene: Alkbh3
Summary
InnateDB Gene IDBG-192856.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Alkbh3
Gene Name alkB, alkylation repair homolog 3 (E. coli)
Synonyms 1700108H04Rik; 1810020C19Rik; Abh3; mABH3
Species Mus musculus
Ensembl Gene ENSMUSG00000040174
Encoded Proteins
IDBP-192858
alkB, alkylation repair homolog 3 (E. coli)
IDBP-258549
alkB, alkylation repair homolog 3 (E. coli)
IDBP-534245
alkB, alkylation repair homolog 3 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166199:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:93980550-94010807
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000040005 ENSMUSP00000038721
ENSMUST00000111240 ENSMUSP00000106871
ENSMUST00000125473
ENSMUST00000126255
ENSMUST00000130403
ENSMUST00000138046
ENSMUST00000126378 ENSMUSP00000122043
ENSMUST00000127231
ENSMUST00000138107
ENSMUST00000156763
ENSMUST00000130289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008198 ferrous iron binding
GO:0016491 oxidoreductase activity
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0043734 DNA-N1-methyladenine dioxygenase activity
GO:0051747 cytosine C-5 DNA demethylase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA dealkylation involved in DNA repair
GO:0008283 cell proliferation
GO:0035552 oxidative single-stranded DNA demethylation
GO:0055114 oxidation-reduction process
GO:0080111 DNA demethylation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000166199
View Gene Order
ENSBTAG00000009518
Not yet available
Pathways
NETPATH
REACTOME
REACT_218005
Reversal of Alkylation Damage By DNA Dioxygenases pathway
REACT_222915
ABH3 mediated Reversal of Alkylation Damage pathway
REACT_233397
DNA Repair pathway
REACT_232874
DNA Damage Reversal pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1662
ABH3 mediated Reversal of Alkylation Damage pathway
REACT_127
DNA Damage Reversal pathway
REACT_2020
Reversal of Alkylation Damage By DNA Dioxygenases pathway
REACT_216
DNA Repair pathway
REACT_206565
ABH3 mediated Reversal of Alkylation Damage pathway
REACT_208817
DNA Damage Reversal pathway
REACT_207880
Reversal of Alkylation Damage By DNA Dioxygenases pathway
REACT_204262
DNA Repair pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272498
RefSeq NM_026944 XM_006500123
OMIM
CCDS CCDS38184
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca