InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hsd17b12

Summary

InnateDB Gene

IDBG-192885.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hsd17b12

Gene Name

hydroxysteroid (17-beta) dehydrogenase 12

Synonyms

2610510O05Rik; AI172963; KIK-I; Kik1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027195

Encoded Proteins

IDBP-192887

hydroxysteroid (17-beta) dehydrogenase 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149084:
This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:94032689-94157964

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028619	ENSMUSP00000028619
ENSMUST00000145967
ENSMUST00000127084
ENSMUST00000146580
ENSMUST00000141955

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0004303	estradiol 17-beta-dehydrogenase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0008201	heparin binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0006703	estrogen biosynthetic process
GO:0008152	metabolic process
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030198	extracellular matrix organization
GO:0055114	oxidation-reduction process