Version 5.4
Mus musculus Gene: Gabarap
Summary
InnateDB Gene IDBG-193040.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gabarap
Gene Name gamma-aminobutyric acid receptor associated protein
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000018567
Encoded Proteins
IDBP-193042
gamma-aminobutyric acid receptor associated protein
IDBP-264208
gamma-aminobutyric acid receptor associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23427251
Gabarap deficient mice are more susceptible to sepsis due to enhanced inflammasome activation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170296:
Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69991143-69994951
Strand Forward strand
Band B3
Transcripts
ENSMUST00000018711 ENSMUSP00000018711
ENSMUST00000108592 ENSMUSP00000104233
ENSMUST00000144443
ENSMUST00000139007
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 78 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0048487 beta-tubulin binding
GO:0050811 GABA receptor binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000226 microtubule cytoskeleton organization
GO:0006914 autophagy
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0015031 protein transport
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000139 Golgi membrane
GO:0000421 autophagic vacuole membrane
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005776 autophagic vacuole
GO:0005790 smooth endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0005930 axoneme
GO:0015629 actin cytoskeleton
GO:0031410 cytoplasmic vesicle
GO:0044297 cell body
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170296
View Gene Order
ENSBTAG00000014883
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04140
Regulation of autophagy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt Q9DCD6
TrEMBL
UniProt Splice Variant
Entrez Gene 56486
UniGene Mm.409975
RefSeq NM_019749
OMIM
CCDS CCDS24928
HPRD
IMGT
MGI ID MGI:1861742
MGI Symbol Gabarap
EMBL AF161587 AK002879 AK011731 AL596185 BC002126 BC024621 BC030350
GenPept AAD47642 AAH02126 AAH24621 AAH30350 BAB22426 BAB27806 CAI35162
RNA Seq Atlas 56486

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca