InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Casp6

Summary

InnateDB Gene

IDBG-193830.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp6

Gene Name

caspase 6

Synonyms

mCASP-6; Mch2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027997

Encoded Proteins

IDBP-193832

caspase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21098228

[Homo sapiens] CASP6 plays an important role in the activation of alveolar macrophages by neutrophils. The cleavage of IRAK3 by CASP6 mediates the degradation of NFKBIA and the induction of TNF upon stimulation by bacterial products.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138794:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:129901425-129914103

Strand

Forward strand

Band

Transcripts

ENSMUST00000029626	ENSMUSP00000029626
ENSMUST00000137314
ENSMUST00000152622

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0042802	identical protein binding