Version 5.4
Mus musculus Gene: Cdk4
Summary
InnateDB Gene IDBG-194056.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdk4
Gene Name cyclin-dependent kinase 4
Synonyms Crk3
Species Mus musculus
Ensembl Gene ENSMUSG00000006728
Encoded Proteins
IDBP-194058
cyclin-dependent kinase 4
IDBP-400376
cyclin-dependent kinase 4
IDBP-533212
cyclin-dependent kinase 4
IDBP-532907
cyclin-dependent kinase 4
IDBP-533557
cyclin-dependent kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135446:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:127063534-127067920
Strand Forward strand
Band D3
Transcripts
ENSMUST00000006911 ENSMUSP00000006911
ENSMUST00000120226 ENSMUSP00000112549
ENSMUST00000133115 ENSMUSP00000122973
ENSMUST00000142558 ENSMUSP00000116190
ENSMUST00000140254
ENSMUST00000135179
ENSMUST00000125682 ENSMUSP00000117234
ENSMUST00000123456
ENSMUST00000145670
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 126 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 53 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 126 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
GO:0032403 protein complex binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0002088 lens development in camera-type eye
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007623 circadian rhythm
GO:0008284 positive regulation of cell proliferation
GO:0009636 response to toxic substance
GO:0010033 response to organic substance
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0031100 organ regeneration
GO:0033574 response to testosterone
GO:0042127 regulation of cell proliferation
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0045727 positive regulation of translation
GO:0045793 positive regulation of cell size
GO:0048146 positive regulation of fibroblast proliferation
GO:0051301 cell division
GO:0051726 regulation of cell cycle
GO:0055093 response to hyperoxia
GO:0071157 negative regulation of cell cycle arrest
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005923 tight junction
GO:0031965 nuclear membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135446
View Gene Order
ENSBTAG00000007160
Not yet available
Pathways
NETPATH
REACTOME
REACT_27235
Meiotic Recombination pathway
REACT_252217
Transcriptional regulation of white adipocyte differentiation pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_200794
Mus musculus biological processes pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_218274
Chromatin organization pathway
REACT_260005
G1 Phase pathway
REACT_263467
Ubiquitin-dependent degradation of Cyclin D1 pathway
REACT_188957
Cellular responses to stress pathway
REACT_188971
Oncogene Induced Senescence pathway
REACT_188804
Cell Cycle pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_188820
Cellular Senescence pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_188576
Developmental Biology pathway
REACT_247652
Ubiquitin-dependent degradation of Cyclin D pathway
REACT_244207
RMTs methylate histone arginines pathway
REACT_198624
Meiosis pathway
REACT_198629
Meiotic recombination pathway
REACT_253623
S Phase pathway
KEGG
mmu04530
Tight junction pathway
mmu05219
Bladder cancer pathway
mmu04115
p53 signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu05218
Melanoma pathway
mmu04110
Cell cycle pathway
mmu05214
Glioma pathway
mmu05222
Small cell lung cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu05212
Pancreatic cancer pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_12
BCR pathway
NetPath_23
TSH pathway
REACTOME
REACT_4
Ubiquitin-dependent degradation of Cyclin D1 pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_27271
Meiotic recombination pathway
REACT_1590
G1 Phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_938
Ubiquitin-dependent degradation of Cyclin D pathway
REACT_115566
Cell Cycle pathway
REACT_169274
Cellular Senescence pathway
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_111183
Meiosis pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_225014
S Phase pathway
REACT_217767
Oncogene Induced Senescence pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_218138
Cyclin D associated events in G1 pathway
REACT_210825
G1 Phase pathway
REACT_206069
Cellular responses to stress pathway
REACT_222447
Meiosis pathway
REACT_207632
Chromatin organization pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_212546
Ubiquitin-dependent degradation of Cyclin D pathway
REACT_220799
Transcriptional regulation of white adipocyte differentiation pathway
REACT_214934
Cell Cycle pathway
REACT_215025
Cellular Senescence pathway
REACT_225657
Oxidative Stress Induced Senescence pathway
REACT_209769
Meiotic recombination pathway
REACT_243659
RMTs methylate histone arginines pathway
REACT_218058
Ubiquitin-dependent degradation of Cyclin D1 pathway
REACT_203215
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_227044
Chromatin modifying enzymes pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa04110
Cell cycle pathway
hsa05218
Melanoma pathway
hsa05219
Bladder cancer pathway
hsa04530
Tight junction pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa04115
p53 signaling pathway pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
atf2_pathway
ATF-2 transcription factor network
myc_activpathway
Validated targets of C-MYC transcriptional activation
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_009870 XM_006543554
OMIM
CCDS CCDS24226
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca