Homo sapiens Gene: CLOCK
Summary
InnateDB Gene IDBG-19411.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLOCK
Gene Name clock homolog (mouse)
Synonyms bHLHe8; KAT13D;
Species Homo sapiens
Ensembl Gene ENSG00000134852
Encoded Proteins
clock homolog (mouse)
clock homolog (mouse)
clock homolog (mouse)
clock homolog (mouse)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:55427903-55547138
Strand Reverse strand
Band q12
Transcripts
ENST00000309964 ENSP00000308741
ENST00000381322 ENSP00000370723
ENST00000435527 ENSP00000396649
ENST00000511124
ENST00000513440 ENSP00000426983
ENST00000479384
ENST00000506747
ENST00000508049
ENST00000506923
ENST00000509151
ENST00000513033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 6 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001047 core promoter binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004402 histone acetyltransferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006325 chromatin organization
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0007623 circadian rhythm
GO:0009648 photoperiodism
GO:0016573 histone acetylation
GO:0032922 circadian regulation of gene expression
GO:0042634 regulation of hair cycle
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050796 regulation of insulin secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051775 response to redox state
GO:0071479 cellular response to ionizing radiation
GO:2000074 regulation of type B pancreatic cell development
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0033391 chromatoid body
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Circadian Clock pathway
Metabolism of lipids and lipoproteins pathway
REV-ERBA represses gene expression pathway
PPARA activates gene expression pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
RORA activates circadian gene expression pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
Circadian rhythm pathway
INOH
PID BIOCARTA
PID NCI
Circadian rhythm pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436975 Hs.658811 Hs.671434 Hs.717498 Hs.727767
RefSeq NM_001267843 NM_004898 XM_005265787 XM_006714054
HUGO
OMIM
CCDS CCDS3500
HPRD 03508
IMGT
EMBL
GenPept
RNA Seq Atlas