InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLOCK

Summary

InnateDB Gene

IDBG-19411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLOCK

Gene Name

clock homolog (mouse)

Synonyms

bHLHe8; KAT13D

Species

Homo sapiens

Ensembl Gene

ENSG00000134852

Encoded Proteins

IDBP-19415

clock homolog (mouse)

IDBP-19417

clock homolog (mouse)

IDBP-368272

clock homolog (mouse)

IDBP-479277

clock homolog (mouse)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:55427903-55547138

Strand

Reverse strand

Band

q12

Transcripts

ENST00000309964	ENSP00000308741
ENST00000381322	ENSP00000370723
ENST00000435527	ENSP00000396649
ENST00000511124
ENST00000513440	ENSP00000426983
ENST00000479384
ENST00000506747
ENST00000508049
ENST00000506923
ENST00000509151
ENST00000513033

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	6 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0001047	core promoter binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006325	chromatin organization
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007283	spermatogenesis
GO:0007623	circadian rhythm
GO:0009648	photoperiodism
GO:0016573	histone acetylation
GO:0032922	circadian regulation of gene expression
GO:0042634	regulation of hair cycle
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050796	regulation of insulin secretion
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051775	response to redox state
GO:0071479	cellular response to ionizing radiation
GO:2000074	regulation of type B pancreatic cell development
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0033391	chromatoid body
GO:0043231	intracellular membrane-bounded organelle