InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Emr1

Summary

InnateDB Gene

IDBG-194190.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Emr1

Gene Name

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

Synonyms

DD7A5-7; EGF-TM7; F4/80; Gpf480; Ly71; TM7LN3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004730

Encoded Proteins

IDBP-194192

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

IDBP-194198

EGF-like module containing, mucin-like, hormone receptor-like sequence 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174837:
This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:57358686-57483529

Strand

Forward strand

Band

Transcripts

ENSMUST00000086763	ENSMUSP00000083971
ENSMUST00000004850	ENSMUSP00000004850

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0071944	cell periphery

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000174837

View Gene Order

ENSBTAG00000007901

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_18372

Class B/2 (Secretin family receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_21340

GPCR ligand binding pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q61549

TrEMBL

Q3S4B0 Q3U9R0 Q6LCD7

UniProt Splice Variant

Entrez Gene

13733

UniGene

Mm.2254

RefSeq

NM_010130 XM_006523602 XM_006523601

OMIM

CCDS

CCDS50160

HPRD

IMGT

MGI ID

MGI:106912

MGI Symbol

Emr1

EMBL

AK133202 AK151682 BC075688 DQ167573 U66888 U66889 X93328

GenPept

AAC53184 AAC53185 AAH75688 ABA02180 BAE21555 BAE30606 CAA63720

RNA Seq Atlas

13733