Version 5.4
Mus musculus Gene: Wt1
Summary
InnateDB Gene IDBG-194872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wt1
Gene Name Wilms tumor 1 homolog
Synonyms D630046I19Rik; Wt-1
Species Mus musculus
Ensembl Gene ENSMUSG00000016458
Encoded Proteins
IDBP-258840
Wilms tumor 1 homolog
IDBP-258842
Wilms tumor 1 homolog
IDBP-538160
Wilms tumor 1 homolog
IDBP-533204
Wilms tumor 1 homolog
IDBP-534708
Wilms tumor 1 homolog
IDBP-535511
Wilms tumor 1 homolog
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. This gene has also been reported to be imprinted, with preferential expression from the maternal allele. [provided by RefSeq, Dec 2010]
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm\'s tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:105126529-105173616
Strand Forward strand
Band E2
Transcripts
ENSMUST00000111099 ENSMUSP00000106728
ENSMUST00000111098 ENSMUSP00000106727
ENSMUST00000143043 ENSMUSP00000117891
ENSMUST00000146842 ENSMUSP00000120702
ENSMUST00000133470 ENSMUSP00000120054
ENSMUST00000139585 ENSMUSP00000123592
ENSMUST00000145107
ENSMUST00000153944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001570 vasculogenesis
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0006309 apoptotic DNA fragmentation
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007281 germ cell development
GO:0007507 heart development
GO:0007530 sex determination
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0009888 tissue development
GO:0017148 negative regulation of translation
GO:0030308 negative regulation of cell growth
GO:0030325 adrenal gland development
GO:0032835 glomerulus development
GO:0032836 glomerular basement membrane development
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0061032 visceral serous pericardium development
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
GO:0072207 metanephric epithelium development
GO:0072284 metanephric S-shaped body morphogenesis
GO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000184937
View Gene Order
ENSBTAG00000047268
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
p73pathway
p73 transcription factor network
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.389339
RefSeq NM_144783
OMIM
CCDS CCDS16496
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca