Version 5.4
Homo sapiens Gene: CCNK
Summary
InnateDB Gene IDBG-19541.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCNK
Gene Name cyclin K
Synonyms CPR4
Species Homo sapiens
Ensembl Gene ENSG00000090061
Encoded Proteins
IDBP-19549
cyclin K
IDBP-598259
cyclin K
IDBP-597390
cyclin K
IDBP-584290
cyclin K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:99481169-99535044
Strand Forward strand
Band q32.2
Transcripts
ENST00000389879 ENSP00000374529
ENST00000557165
ENST00000553636
ENST00000557441 ENSP00000450792
ENST00000555049 ENSP00000452307
ENST00000555842 ENSP00000450440
ENST00000556641
ENST00000555942
ENST00000553865
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0019901 protein kinase binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0001701 in utero embryonic development
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007067 mitotic nuclear division
GO:0071157 negative regulation of cell cycle arrest
Cellular Component
GO:0002944 cyclin K-CDK12 complex
GO:0002945 cyclin K-CDK13 complex
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021258
View Gene Order
ENSBTAG00000018636
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.510409 Hs.605039
RefSeq NM_001099402 XM_005268154
HUGO
OMIM
CCDS CCDS45160
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca