Mus musculus Gene: Tbx5
Summary
InnateDB Gene IDBG-195451.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbx5
Gene Name T-box 5
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000018263
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089225:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:119834663-119885218
Strand Forward strand
Band F
Transcripts
ENSMUST00000018407 ENSMUSP00000018407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0003166 bundle of His development
GO:0003181 atrioventricular valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003218 cardiac left ventricle formation
GO:0003229 ventricular cardiac muscle tissue development
GO:0003281 ventricular septum development
GO:0003283 atrial septum development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007267 cell-cell signaling
GO:0007389 pattern specification process
GO:0007507 heart development
GO:0008285 negative regulation of cell proliferation
GO:0030262 apoptotic nuclear changes
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030336 negative regulation of cell migration
GO:0035115 embryonic forelimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051891 positive regulation of cardioblast differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0060039 pericardium development
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060413 atrial septum morphogenesis
GO:0072513 positive regulation of secondary heart field cardioblast proliferation
GO:1900117 regulation of execution phase of apoptosis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gene Expression pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Generic Transcription Pathway pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Generic Transcription Pathway pathway
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
Gene Expression pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.103636
RefSeq NM_011537 XM_006530278 XM_006530279 XM_006530280 XM_006530281 XM_006530282 XM_006530283
OMIM
CCDS CCDS19615
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas