InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mgst1

Summary

InnateDB Gene

IDBG-195593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgst1

Gene Name

microsomal glutathione S-transferase 1

Synonyms

1500002K10Rik; Gst

Species

Mus musculus

Ensembl Gene

ENSMUSG00000008540

Encoded Proteins

IDBP-195595

microsomal glutathione S-transferase 1

IDBP-400388

microsomal glutathione S-transferase 1

IDBP-400386

microsomal glutathione S-transferase 1

IDBP-400385

microsomal glutathione S-transferase 1

IDBP-400389

microsomal glutathione S-transferase 1

IDBP-541307

microsomal glutathione S-transferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008394:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:138140316-138156755

Strand

Forward strand

Band

Transcripts

ENSMUST00000008684	ENSMUSP00000008684
ENSMUST00000118091	ENSMUSP00000112923
ENSMUST00000120302	ENSMUSP00000113257
ENSMUST00000120230	ENSMUSP00000113859
ENSMUST00000120939	ENSMUSP00000112646
ENSMUST00000140932
ENSMUST00000125810	ENSMUSP00000114222

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004364	glutathione transferase activity
GO:0004602	glutathione peroxidase activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043295	glutathione binding

Biological Process

GO:0006749	glutathione metabolic process
GO:0010243	response to organonitrogen compound
GO:0032496	response to lipopolysaccharide
GO:0033327	Leydig cell differentiation
GO:0042493	response to drug
GO:0055114	oxidation-reduction process
GO:0070207	protein homotrimerization
GO:0071449	cellular response to lipid hydroperoxide

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell