Mus musculus Gene: Mgst1
Summary
InnateDB Gene IDBG-195593.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mgst1
Gene Name microsomal glutathione S-transferase 1
Synonyms 1500002K10Rik; Gst;
Species Mus musculus
Ensembl Gene ENSMUSG00000008540
Encoded Proteins
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
microsomal glutathione S-transferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000008394:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:138140316-138156755
Strand Forward strand
Band G1
Transcripts
ENSMUST00000008684 ENSMUSP00000008684
ENSMUST00000118091 ENSMUSP00000112923
ENSMUST00000120302 ENSMUSP00000113257
ENSMUST00000120230 ENSMUSP00000113859
ENSMUST00000120939 ENSMUSP00000112646
ENSMUST00000140932
ENSMUST00000125810 ENSMUSP00000114222
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043295 glutathione binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0010243 response to organonitrogen compound
GO:0032496 response to lipopolysaccharide
GO:0033327 Leydig cell differentiation
GO:0042493 response to drug
GO:0055114 oxidation-reduction process
GO:0070207 protein homotrimerization
GO:0071449 cellular response to lipid hydroperoxide
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005778 peroxisomal membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0045177 apical part of cell
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Aflatoxin activation and detoxification pathway
Phase II conjugation pathway
Metabolism pathway
Glutathione conjugation pathway
Biological oxidations pathway
KEGG
Glutathione metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Glutathione conjugation pathway
Aflatoxin activation and detoxification pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Glutathione metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.426978
RefSeq NM_019946 XM_006506418
OMIM
CCDS CCDS20668
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas