Version 5.4
Mus musculus Gene: Pik3c2g
Summary
InnateDB Gene IDBG-195657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pik3c2g
Gene Name phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
Synonyms C80387; PI3K-C2-gamma
Species Mus musculus
Ensembl Gene ENSMUSG00000030228
Encoded Proteins
IDBP-195659
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
IDBP-257213
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
IDBP-789538
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
IDBP-789541
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
IDBP-789542
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
IDBP-789544
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
IDBP-789550
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
IDBP-789551
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139144:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:139587221-139969284
Strand Forward strand
Band G2
Transcripts
ENSMUST00000087657 ENSMUSP00000084939
ENSMUST00000111868 ENSMUSP00000107499
ENSMUST00000188066 ENSMUSP00000140123
ENSMUST00000190962 ENSMUSP00000141141
ENSMUST00000187618 ENSMUSP00000141025
ENSMUST00000186585
ENSMUST00000185968 ENSMUSP00000140368
ENSMUST00000187069
ENSMUST00000191013
ENSMUST00000189374 ENSMUSP00000139763
ENSMUST00000187223 ENSMUSP00000140589
ENSMUST00000187448
ENSMUST00000191591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139144
View Gene Order
ENSBTAG00000020715
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121025
Synthesis of PIPs at the plasma membrane pathway
REACT_120836
Synthesis of PIPs at the Golgi membrane pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121175
PI Metabolism pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 18705
UniGene
RefSeq NM_011084 NM_207683
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:1203730
MGI Symbol Pik3c2g
EMBL
GenPept
RNA Seq Atlas 18705

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca