Mus musculus Gene: Pik3c2g
Summary
InnateDB Gene IDBG-195657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pik3c2g
Gene Name phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
Synonyms C80387; PI3K-C2-gamma;
Species Mus musculus
Ensembl Gene ENSMUSG00000030228
Encoded Proteins
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139144:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:139587221-139969284
Strand Forward strand
Band G2
Transcripts
ENSMUST00000087657 ENSMUSP00000084939
ENSMUST00000111868 ENSMUSP00000107499
ENSMUST00000188066 ENSMUSP00000140123
ENSMUST00000190962 ENSMUSP00000141141
ENSMUST00000187618 ENSMUSP00000141025
ENSMUST00000186585
ENSMUST00000185968 ENSMUSP00000140368
ENSMUST00000187069
ENSMUST00000191013
ENSMUST00000189374 ENSMUSP00000139763
ENSMUST00000187223 ENSMUSP00000140589
ENSMUST00000187448
ENSMUST00000191591
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Inositol phosphate metabolism pathway
Phosphatidylinositol signaling system pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Synthesis of PIPs at the plasma membrane pathway
Synthesis of PIPs at the Golgi membrane pathway
PI Metabolism pathway
Phospholipid metabolism pathway
Metabolism pathway
KEGG
Inositol phosphate metabolism pathway
Phosphatidylinositol signaling system pathway
INOH
PID BIOCARTA
Ccr3 signaling in eosinophils [Biocarta view]
Phospholipids as signalling intermediaries [Biocarta view]
Cxcr4 signaling pathway [Biocarta view]
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011084 NM_207683
OMIM
CCDS
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas