InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Irf8

Summary

InnateDB Gene

IDBG-196509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf8

Gene Name

interferon regulatory factor 8

Synonyms

AI893568; ICSBP; Icsbp1; IRF-8; Myls

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041515

Encoded Proteins

IDBP-196511

interferon regulatory factor 8

IDBP-535532

interferon regulatory factor 8

IDBP-533566

interferon regulatory factor 8

IDBP-541699

interferon regulatory factor 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22942423

De-SUMOylation of IRF8 at residue Lys310 acts as a molecular mechanism to trigger innate immune responses in activated macrophages.

PMID 26843324

Irf8-Ifng circuit is a novel gastric innate immune mechanism in the host defense against infection with Helicobacter pylori.

InnateDB Annotation from Orthologs

Summary

PMID 16484229

[Homo sapiens] IRF8 interacts with TRAF6 to modulate TLR signalling and may also contribute to the cross-talk between IFN-gamma and TLR signalling pathways.

PMID 18469857

[Homo sapiens] IRF8 belongs to a family of interferon (IFN) regulatory factors that modulate various important physiologic processes including host defence, cell growth and differentiation and immune regulation.

PMID 22942423

[Homo sapiens] De-SUMOylation of IRF8 at residue Lys310 acts as a molecular mechanism to trigger innate immune responses in activated macrophages. (Demonstrated in mice)

Entrez Gene

Summary

The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:120736358-120756694

Strand

Forward strand

Band

Transcripts

ENSMUST00000047737	ENSMUSP00000040245
ENSMUST00000162775
ENSMUST00000162658	ENSMUSP00000125443
ENSMUST00000162001	ENSMUSP00000125029
ENSMUST00000160943	ENSMUSP00000125447
ENSMUST00000160388
ENSMUST00000160594

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 337 experimentally validated interaction(s) in this database.
They are also associated with 70 interaction(s) predicted by orthology.

Experimentally validated
Total	337 [view]
Protein-Protein	23 [view]
Protein-DNA	314 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	70 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006909	phagocytosis
GO:0006955	immune response
GO:0009617	response to bacterium
GO:0030099	myeloid cell differentiation
GO:0032729	positive regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0042742	defense response to bacterium
GO:0042832	defense response to protozoan
GO:0044130	negative regulation of growth of symbiont in host
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060261	positive regulation of transcription initiation from RNA polymerase II promoter
GO:0071222	cellular response to lipopolysaccharide