InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adh4

Summary

InnateDB Gene

IDBG-196561.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adh4

Gene Name

alcohol dehydrogenase 4 (class II), pi polypeptide

Synonyms

Adh2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037797

Encoded Proteins

IDBP-196563

alcohol dehydrogenase 4 (class II), pi polypeptide

IDBP-535406

alcohol dehydrogenase 4 (class II), pi polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198099:
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:138415466-138430892

Strand

Forward strand

Band

Transcripts

ENSMUST00000013458	ENSMUSP00000013458
ENSMUST00000162260
ENSMUST00000161312	ENSMUSP00000124163

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003960	NADPH:quinone reductase activity
GO:0004022	alcohol dehydrogenase (NAD) activity
GO:0004024	alcohol dehydrogenase activity, zinc-dependent
GO:0004032	alditol:NADP+ 1-oxidoreductase activity
GO:0004745	retinol dehydrogenase activity
GO:0005503	all-trans retinal binding
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0019115	benzaldehyde dehydrogenase activity
GO:0019841	retinol binding
GO:0035276	ethanol binding
GO:0051287	NAD binding

Biological Process

GO:0001523	retinoid metabolic process
GO:0006066	alcohol metabolic process
GO:0006067	ethanol metabolic process
GO:0006069	ethanol oxidation
GO:0006081	cellular aldehyde metabolic process
GO:0042572	retinol metabolic process
GO:0046164	alcohol catabolic process
GO:0055114	oxidation-reduction process
GO:1901661	quinone metabolic process