Version 5.4
Mus musculus Gene: Manf
Summary
InnateDB Gene IDBG-196820.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Manf
Gene Name mesencephalic astrocyte-derived neurotrophic factor
Synonyms 3230402M22Rik; AA407711; AA408789; AA673178; Armet; D17914; D18Mgi17
Species Mus musculus
Ensembl Gene ENSMUSG00000032575
Encoded Proteins
IDBP-196822
mesencephalic astrocyte-derived neurotrophic factor
IDBP-541770
mesencephalic astrocyte-derived neurotrophic factor
IDBP-541536
mesencephalic astrocyte-derived neurotrophic factor
IDBP-540434
mesencephalic astrocyte-derived neurotrophic factor
IDBP-532095
mesencephalic astrocyte-derived neurotrophic factor
IDBP-532755
mesencephalic astrocyte-derived neurotrophic factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145050:
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010]
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:106838312-106891979
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000069036 ENSMUSP00000066534
ENSMUST00000159620 ENSMUSP00000123907
ENSMUST00000161272 ENSMUSP00000125424
ENSMUST00000159283 ENSMUSP00000124562
ENSMUST00000160503 ENSMUSP00000124453
ENSMUST00000160978 ENSMUSP00000124791
ENSMUST00000162801
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0044822 poly(A) RNA binding
Biological Process
GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
Cellular Component
GO:0005575 cellular_component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145050
View Gene Order
ENSBTAG00000031797
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 74840
UniGene Mm.29778 Mm.471819
RefSeq NM_029103
OMIM
CCDS CCDS23486
HPRD
IMGT
MGI ID MGI:1922090
MGI Symbol Manf
EMBL
GenPept
RNA Seq Atlas 74840

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca