Homo sapiens Gene: IFNAR2
Summary
InnateDB Gene IDBG-1973.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNAR2
Gene Name interferon (alpha, beta and omega) receptor 2
Synonyms IFN-alpha-REC; IFN-R; IFNABR; IFNARB;
Species Homo sapiens
Ensembl Gene ENSG00000159110
Encoded Proteins
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
The interferon alpha receptor is composed of two subunits: IFNAR1 and IFNAR2;IL10RB. Binding of interferon (IFN)-alpha to IFNAR2;IL10RB results in STAT2 binding and the initiation of the IFN signaling cascade.
Type I interferons (IFNs) play an important role in innate immunity to protozoan parasites by binding the IFN alpha receptor, composed of IFNAR1 and IFNAR2;IL10RB, and regulating neutrophil/monocyte recruitment, neutrophil turnover, and Leishmania infection.
Entrez Gene
Summary The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:33229901-33265675
Strand Forward strand
Band q22.11
Transcripts
ENST00000382264 ENSP00000371699
ENST00000342136 ENSP00000343957
ENST00000342101 ENSP00000343289
ENST00000382238 ENSP00000371673
ENST00000404220 ENSP00000384309
ENST00000420068
ENST00000443073 ENSP00000403569
ENST00000413881 ENSP00000413160
ENST00000447980 ENSP00000402311
ENST00000417007 ENSP00000398799
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 32 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004905 type I interferon receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019962 type I interferon binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007166 cell surface receptor signaling pathway
GO:0007259 JAK-STAT cascade
GO:0008283 cell proliferation
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0035455 response to interferon-alpha
GO:0045087 innate immune response (InnateDB)
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Hepatitis C pathway
INOH
IFN alpha signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
Ifn alpha signaling pathway [Biocarta view]
Bone remodeling [Biocarta view]
Il-10 anti-inflammatory signaling pathway [Biocarta view]
PID NCI
Downstream signaling in na´ve CD8+ T cells
Regulation of Telomerase
Cross-References
SwissProt P48551
TrEMBL C9JCU0 C9JM33 C9K067 F8WDE1 H7C176
UniProt Splice Variant
Entrez Gene 3455
UniGene Hs.512211 Hs.708195
RefSeq NM_000874 NM_001289125 NM_001289126 NM_001289128 NM_207584 NM_207585
HUGO HGNC:5433
OMIM 602376
CCDS CCDS13621 CCDS13622 CCDS74782
HPRD
IMGT
EMBL AK293059 AP000292 AP000293 AP000294 AP000295 AY740397 CH471079 CR541817 L41942 L41943 L41944 L42238 L42239 L42240 L42241 L42242 L42243 L42323 U29584 X77722 X89772 X89814
GenPept AAB46413 AAB46414 AAB46415 AAB46417 AAB46418 AAB46419 AAC50202 AAU21038 BAF85748 CAA54785 CAA61914 CAA61940 CAG46616 EAX09842 EAX09843 EAX09844 EAX09846
RNA Seq Atlas 3455