Homo sapiens Gene: IFNAR2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-1973.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | IFNAR2 | ||||||||||||||||||||||
Gene Name | interferon (alpha, beta and omega) receptor 2 | ||||||||||||||||||||||
Synonyms | IFN-alpha-REC; IFN-R; IFNABR; IFNARB | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000159110 | ||||||||||||||||||||||
Encoded Proteins |
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
interferon (alpha, beta and omega) receptor 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
The interferon alpha receptor is composed of two subunits: IFNAR1 and IFNAR2;IL10RB. Binding of interferon (IFN)-alpha to IFNAR2;IL10RB results in STAT2 binding and the initiation of the IFN signaling cascade.
Type I interferons (IFNs) play an important role in innate immunity to protozoan parasites by binding the IFN alpha receptor, composed of IFNAR1 and IFNAR2;IL10RB, and regulating neutrophil/monocyte recruitment, neutrophil turnover, and Leishmania infection.
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Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 21:33229901-33265675 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q22.11 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||
KEGG |
Cytokine-cytokine receptor interaction pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
Hepatitis C pathway
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INOH |
JAK STAT pathway and regulation pathway
IFN alpha signaling pathway
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PID NCI |
Downstream signaling in naïve CD8+ T cells
Regulation of Telomerase
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.512211 Hs.708195 | ||||||||||||||||||||||
RefSeq | NM_000874 NM_001289125 NM_001289126 NM_001289128 NM_207584 NM_207585 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS13621 CCDS13622 CCDS74782 | ||||||||||||||||||||||
HPRD | 03850 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||