Version 5.4
Homo sapiens Gene: AP3M2
Summary
InnateDB Gene IDBG-19771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP3M2
Gene Name adaptor-related protein complex 3, mu 2 subunit
Synonyms AP47B; CLA20; P47B
Species Homo sapiens
Ensembl Gene ENSG00000070718
Encoded Proteins
IDBP-19773
adaptor-related protein complex 3, mu 2 subunit
IDBP-236470
adaptor-related protein complex 3, mu 2 subunit
IDBP-473470
adaptor-related protein complex 3, mu 2 subunit
IDBP-483134
adaptor-related protein complex 3, mu 2 subunit
IDBP-480812
adaptor-related protein complex 3, mu 2 subunit
IDBP-478175
adaptor-related protein complex 3, mu 2 subunit
IDBP-475050
adaptor-related protein complex 3, mu 2 subunit
IDBP-474467
adaptor-related protein complex 3, mu 2 subunit
IDBP-480797
adaptor-related protein complex 3, mu 2 subunit
IDBP-474207
adaptor-related protein complex 3, mu 2 subunit
IDBP-477938
adaptor-related protein complex 3, mu 2 subunit
IDBP-601223
adaptor-related protein complex 3, mu 2 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42152946-42171673
Strand Forward strand
Band p11.21
Transcripts
ENST00000174653 ENSP00000174653
ENST00000396926 ENSP00000380132
ENST00000518421 ENSP00000428787
ENST00000517865 ENSP00000430200
ENST00000520685
ENST00000521280 ENSP00000430616
ENST00000522288 ENSP00000429515
ENST00000521235
ENST00000517969 ENSP00000430538
ENST00000517922 ENSP00000429435
ENST00000523249
ENST00000517499 ENSP00000429037
ENST00000521899
ENST00000522320
ENST00000522606 ENSP00000428279
ENST00000520689 ENSP00000429804
ENST00000530375 ENSP00000431918
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0008089 anterograde axon cargo transport
GO:0016192 vesicle-mediated transport
GO:0048490 anterograde synaptic vesicle transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0030119 AP-type membrane coat adaptor complex
GO:0030131 clathrin adaptor complex
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031539
View Gene Order
ENSBTAG00000001243
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595344 Hs.654529 Hs.675101
RefSeq NM_001134296 NM_006803 XM_006716276
HUGO
OMIM
CCDS CCDS6125
HPRD 09801
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca