Homo sapiens Gene: AP3M2
Summary
InnateDB Gene IDBG-19771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP3M2
Gene Name adaptor-related protein complex 3, mu 2 subunit
Synonyms AP47B; CLA20; P47B;
Species Homo sapiens
Ensembl Gene ENSG00000070718
Encoded Proteins
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
adaptor-related protein complex 3, mu 2 subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42152946-42171673
Strand Forward strand
Band p11.21
Transcripts
ENST00000174653 ENSP00000174653
ENST00000396926 ENSP00000380132
ENST00000518421 ENSP00000428787
ENST00000517865 ENSP00000430200
ENST00000520685
ENST00000521280 ENSP00000430616
ENST00000522288 ENSP00000429515
ENST00000521235
ENST00000517969 ENSP00000430538
ENST00000517922 ENSP00000429435
ENST00000523249
ENST00000517499 ENSP00000429037
ENST00000521899
ENST00000522320
ENST00000522606 ENSP00000428279
ENST00000520689 ENSP00000429804
ENST00000530375 ENSP00000431918
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0008089 anterograde axon cargo transport
GO:0016192 vesicle-mediated transport
GO:0048490 anterograde synaptic vesicle transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0030119 AP-type membrane coat adaptor complex
GO:0030131 clathrin adaptor complex
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P53677
TrEMBL E5RI83 E5RJ52 H0YBM0
UniProt Splice Variant
Entrez Gene 10947
UniGene Hs.595344 Hs.654529 Hs.675101
RefSeq NM_001134296 NM_006803 XM_006716276
HUGO HGNC:570
OMIM 610469
CCDS CCDS6125
HPRD 09801
IMGT
EMBL AC103724 AK315228 BC056398 CH471080 D38293
GenPept AAH56398 BAA07415 BAG37657 EAW63236 EAW63237 EAW63238
RNA Seq Atlas 10947