Mus musculus Gene: Wnt4
Summary
InnateDB Gene IDBG-198435.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wnt4
Gene Name wingless-related MMTV integration site 4
Synonyms Wnt-4;
Species Mus musculus
Ensembl Gene ENSMUSG00000036856
Encoded Proteins
wingless-related MMTV integration site 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162552:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:137277489-137299726
Strand Forward strand
Band D3
Transcripts
ENSMUST00000045747 ENSMUSP00000036580
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005102 receptor binding
GO:0005109 frizzled binding
GO:0005515 protein binding
Biological Process
GO:0001656 metanephros development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001837 epithelial to mesenchymal transition
GO:0001838 embryonic epithelial tube formation
GO:0001889 liver development
GO:0006702 androgen biosynthetic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0007276 gamete generation
GO:0007548 sex differentiation
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009267 cellular response to starvation
GO:0010629 negative regulation of gene expression
GO:0010894 negative regulation of steroid biosynthetic process
GO:0016055 Wnt signaling pathway
GO:0018345 protein palmitoylation
GO:0022407 regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030237 female sex determination
GO:0030325 adrenal gland development
GO:0030336 negative regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0032321 positive regulation of Rho GTPase activity
GO:0032349 positive regulation of aldosterone biosynthetic process
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033077 T cell differentiation in thymus
GO:0033080 immature T cell proliferation in thymus
GO:0035239 tube morphogenesis
GO:0035567 non-canonical Wnt signaling pathway
GO:0038030 non-canonical Wnt receptor signaling pathway via MAPK cascade
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042445 hormone metabolic process
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045836 positive regulation of meiosis
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048599 oocyte development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048856 anatomical structure development
GO:0051145 smooth muscle cell differentiation
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060070 canonical Wnt signaling pathway
GO:0060126 somatotropin secreting cell differentiation
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation
GO:0060231 mesenchymal to epithelial transition
GO:0060748 tertiary branching involved in mammary gland duct morphogenesis
GO:0060993 kidney morphogenesis
GO:0061045 negative regulation of wound healing
GO:0061180 mammary gland epithelium development
GO:0061184 positive regulation of dermatome development
GO:0061205 paramesonephric duct development
GO:0061369 negative regulation of testicular blood vessel morphogenesis
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072033 renal vesicle formation
GO:0072034 renal vesicle induction
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072164 mesonephric tubule development
GO:0072174 metanephric tubule formation
GO:0072210 metanephric nephron development
GO:0072273 metanephric nephron morphogenesis
GO:0090002 establishment of protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:2000019 negative regulation of male gonad development
GO:2000066 positive regulation of cortisol biosynthetic process
GO:2000225 negative regulation of testosterone biosynthetic process
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0009986 cell surface
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Signaling by Wnt pathway
WNT ligand biogenesis and trafficking pathway
Signaling by WNT in cancer pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Wnt pathway
REACTOME
PCP/CE pathway pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
WNT ligand biogenesis and trafficking pathway
negative regulation of TCF-dependent signaling by WNT ligand antagonists pathway
TCF dependent signaling in response to WNT pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
GPCR ligand binding pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Class B/2 (Secretin family receptors) pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P22724
TrEMBL Q3ZB23 Q91ZN8
UniProt Splice Variant
Entrez Gene 22417
UniGene Mm.20355
RefSeq NM_009523
OMIM
CCDS CCDS18815
HPRD
IMGT
MGI ID MGI:98957
MGI Symbol Wnt4
EMBL AF414100 BC101962 BC103560 BC103561 BC103562 CH466552 M89797
GenPept AAA40566 AAI01963 AAI03561 AAI03562 AAI03563 AAL10394 EDL29922
RNA Seq Atlas 22417