InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ncf2

Summary

InnateDB Gene

IDBG-198618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncf2

Gene Name

neutrophil cytosolic factor 2

Synonyms

Ncf-2; NOXA2; p67phox

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026480

Encoded Proteins

IDBP-198620

neutrophil cytosolic factor 2

IDBP-789169

neutrophil cytosolic factor 2

IDBP-789171

neutrophil cytosolic factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116701:
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:152800194-152836991

Strand

Forward strand

Band

Transcripts

ENSMUST00000027754	ENSMUSP00000027754
ENSMUST00000186568	ENSMUSP00000140404
ENSMUST00000190323	ENSMUSP00000139774
ENSMUST00000187641
ENSMUST00000189135
ENSMUST00000187235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0006742	NADP catabolic process
GO:0006801	superoxide metabolic process
GO:0007568	aging
GO:0009749	response to glucose
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0032496	response to lipopolysaccharide
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0033993	response to lipid
GO:0034616	response to laminar fluid shear stress
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0043525	positive regulation of neuron apoptotic process
GO:0045777	positive regulation of blood pressure
GO:0055093	response to hyperoxia
GO:0055114	oxidation-reduction process