InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ip6k1

Summary

InnateDB Gene

IDBG-198951.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ip6k1

Gene Name

inositol hexaphosphate kinase 1

Synonyms

1200016D08Rik; AU022776; Ihpk1; InsP6; InsP6k1; Itpk6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032594

Encoded Proteins

IDBP-198953

inositol hexaphosphate kinase 1

IDBP-626328

inositol hexaphosphate kinase 1

IDBP-741850

IDBP-742618

IDBP-742688

IDBP-742109

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21685907

Ip6k1 disruption results in the augmentation of downstream phosphatidylinositol-(3,4,5)-triphosphate signalling in neutrophils. As a result, these neutrophils exhibited greater phagocytic and bactericidal ability and amplified NADPH oxidase-mediated production of superoxide.

InnateDB Annotation from Orthologs

Summary

PMID 21685907

[Homo sapiens] IP6K1 disruption results in the augmentation of downstream phosphatidylinositol-(3,4,5)-triphosphate signalling in neutrophils. As a result, these neutrophils exhibited greater phagocytic and bactericidal ability and amplified NADPH oxidase-mediated production of superoxide.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176095:
This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:108002501-108048780

Strand

Forward strand

Band

Transcripts

ENSMUST00000035214	ENSMUSP00000035214
ENSMUST00000167159
ENSMUST00000164395	ENSMUSP00000128534
ENSMUST00000175874	ENSMUSP00000135747
ENSMUST00000176566	ENSMUSP00000135350
ENSMUST00000176613	ENSMUSP00000135587
ENSMUST00000177396
ENSMUST00000177158	ENSMUSP00000134754
ENSMUST00000176854
ENSMUST00000175908

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000832	inositol hexakisphosphate 5-kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity
GO:0052723	inositol hexakisphosphate 1-kinase activity
GO:0052724	inositol hexakisphosphate 3-kinase activity

Biological Process

GO:0006020	inositol metabolic process
GO:0016310	phosphorylation
GO:0032958	inositol phosphate biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0046854	phosphatidylinositol phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000176095

View Gene Order

ENSBTAG00000011595

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_196480

Synthesis of IPs in the nucleus pathway

REACT_196482

Synthesis of pyrophosphates in the cytosol pathway

REACT_196476

Inositol phosphate metabolism pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_150188

Synthesis of pyrophosphates in the cytosol pathway

REACT_150275

Synthesis of IPs in the nucleus pathway

REACT_150154

Inositol phosphate metabolism pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.276155 Mm.397781

RefSeq

NM_013785

OMIM

CCDS

CCDS23514

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas