Mus musculus Gene: Ipo8
Summary
InnateDB Gene IDBG-199136.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ipo8
Gene Name importin 8
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000040029
Encoded Proteins
importin 8
importin 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000133704:
The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:148770683-148831467
Strand Reverse strand
Band G3
Transcripts
ENSMUST00000048418 ENSMUSP00000046759
ENSMUST00000136896
ENSMUST00000147955
ENSMUST00000123842
ENSMUST00000145743
ENSMUST00000144357
ENSMUST00000145960 ENSMUSP00000117365
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008536 Ran GTPase binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Transcriptional regulation by small RNAs pathway
Gene Expression pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transcriptional regulation by small RNAs pathway
Gene Expression pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q7TMY7
TrEMBL
UniProt Splice Variant
Entrez Gene 320727
UniGene Mm.260105 Mm.413064 Mm.468361
RefSeq NM_001081113 XM_006507065 XM_006507066 XM_006507067 XM_006507068 XM_006536086 XM_006536087 XM_006536088 XM_006536089
OMIM
CCDS CCDS39719
HPRD
IMGT
MGI ID MGI:2444611
MGI Symbol Ipo8
EMBL AK047854 BC024474 BC027360 BC044819 BC054373 BC151036 BC151052 BQ770006 CD350256 CH466572 CU302294
GenPept AAH24474 AAH27360 AAH44819 AAH54373 AAI51037 AAI51053 BAC33175 CAQ52306 EDL10748
RNA Seq Atlas 320727