Version 5.4
Homo sapiens Gene: MLXIPL
Summary
InnateDB Gene IDBG-20029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLXIPL
Gene Name MLX interacting protein-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000009950
Encoded Proteins
IDBP-20031
MLX interacting protein-like
IDBP-20033
MLX interacting protein-like
IDBP-20037
MLX interacting protein-like
IDBP-377671
MLX interacting protein-like
IDBP-377672
MLX interacting protein-like
IDBP-377681
MLX interacting protein-like
IDBP-377682
MLX interacting protein-like
IDBP-377684
MLX interacting protein-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:73593194-73624543
Strand Reverse strand
Band q11.23
Transcripts
ENST00000313375 ENSP00000320886
ENST00000354613 ENSP00000346629
ENST00000345114 ENSP00000343767
ENST00000414749 ENSP00000412330
ENST00000429400 ENSP00000406296
ENST00000434326 ENSP00000392636
ENST00000453275 ENSP00000395172
ENST00000456640 ENSP00000402615
ENST00000467221
ENST00000476404
ENST00000488212
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0035538 carbohydrate response element binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006112 energy reserve metabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008284 positive regulation of cell proliferation
GO:0009653 anatomical structure morphogenesis
GO:0010255 glucose mediated signaling pathway
GO:0031325 positive regulation of cellular metabolic process
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035556 intracellular signal transduction
GO:0042304 regulation of fatty acid biosynthetic process
GO:0042593 glucose homeostasis
GO:0044281 small molecule metabolic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045821 positive regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046889 positive regulation of lipid biosynthetic process
GO:0055089 fatty acid homeostasis
GO:0070328 triglyceride homeostasis
GO:0071157 negative regulation of cell cycle arrest
GO:0090324 negative regulation of oxidative phosphorylation
GO:2000505 regulation of energy homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005373
View Gene Order
ENSBTAG00000009153
Not yet available
Pathways
NETPATH
REACTOME
REACT_705
PP2A-mediated dephosphorylation of key metabolic factors pathway
REACT_2122
ChREBP activates metabolic gene expression pathway
REACT_1525
PKA-mediated phosphorylation of key metabolic factors pathway
REACT_1988
AMPK inhibits chREBP transcriptional activation activity pathway
REACT_1505
Integration of energy metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.647055
RefSeq NM_032951 NM_032952 NM_032953 NM_032954 XM_005250399
HUGO
OMIM
CCDS CCDS47605 CCDS47606 CCDS5553 CCDS5554
HPRD 12033
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca