Mus musculus Gene: Crk
Summary
InnateDB Gene IDBG-200571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crk
Gene Name v-crk sarcoma virus CT10 oncogene homolog (avian)
Synonyms c-Crk; Crk-I; Crk-II; Crk-III; Crk3; CrkIII; Crko; p38;
Species Mus musculus
Ensembl Gene ENSMUSG00000017776
Encoded Proteins
v-crk sarcoma virus CT10 oncogene homolog (avian)
v-crk sarcoma virus CT10 oncogene homolog (avian)
v-crk sarcoma virus CT10 oncogene homolog (avian)
v-crk sarcoma virus CT10 oncogene homolog (avian)
v-crk sarcoma virus CT10 oncogene homolog (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:75679259-75706908
Strand Forward strand
Band B5
Transcripts
ENSMUST00000093115 ENSMUSP00000090803
ENSMUST00000017920 ENSMUSP00000017920
ENSMUST00000108426 ENSMUSP00000104064
ENSMUST00000108425 ENSMUSP00000104063
ENSMUST00000147718 ENSMUSP00000116527
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 239 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 239 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0030674 protein binding, bridging
GO:0042169 SH2 domain binding
GO:0045309 protein phosphorylated amino acid binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0009967 positive regulation of signal transduction
GO:0032319 regulation of Rho GTPase activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0035020 regulation of Rac protein signal transduction
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Hemostasis pathway
Signaling by Insulin receptor pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Signal attenuation pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Downstream signal transduction pathway
Insulin receptor signalling cascade pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
Signaling by Interleukins pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Signaling by PDGF pathway
p130Cas linkage to MAPK signaling for integrins pathway
NGF signalling via TRKA from the plasma membrane pathway
ARMS-mediated activation pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
Prolonged ERK activation events pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Regulation of signaling by CBL pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Chronic myeloid leukemia pathway
INOH
PDGF signaling pathway pathway
Integrin signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Signalling by NGF pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by VEGF pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Immune System pathway
Downstream signal transduction pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
Signalling to ERKs pathway
NGF signalling via TRKA from the plasma membrane pathway
Platelet Aggregation (Plug Formation) pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
ARMS-mediated activation pathway
Signal attenuation pathway
p130Cas linkage to MAPK signaling for integrins pathway
Prolonged ERK activation events pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Hemostasis pathway
Regulation of signaling by CBL pathway
KEGG
MAPK signaling pathway pathway
ErbB signaling pathway pathway
Chemokine signaling pathway pathway
Focal adhesion pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Insulin signaling pathway pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
Pathways in cancer pathway
Renal cell carcinoma pathway
Chronic myeloid leukemia pathway
INOH
PDGF signaling pathway pathway
Integrin signaling pathway pathway
HGF signaling pathway pathway
PID BIOCARTA
PID NCI
EPHA forward signaling
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
LPA receptor mediated events
CXCR4-mediated signaling events
VEGFR3 signaling in lymphatic endothelium
Signaling events mediated by PTP1B
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Nectin adhesion pathway
Signaling events mediated by focal adhesion kinase
IGF1 pathway
EPHB forward signaling
RAC1 signaling pathway
Endothelins
Angiopoietin receptor Tie2-mediated signaling
Signaling events regulated by Ret tyrosine kinase
Alpha4 beta1 integrin signaling events
PDGFR-alpha signaling pathway
PDGFR-beta signaling pathway
Insulin Pathway
Cross-References
SwissProt Q64010
TrEMBL Q3TQV3 Q5ND50 Q5ND51 Q8BPE7 Q8JZR2
UniProt Splice Variant
Entrez Gene 12928
UniGene Mm.280125 Mm.441530 Mm.472542 Mm.487139
RefSeq NM_001277219 NM_001277221 NM_133656 XM_006532125
OMIM
CCDS CCDS25055 CCDS70241 CCDS70242
HPRD
IMGT
MGI ID MGI:88508
MGI Symbol Crk
EMBL AK028179 AK028488 AK036905 AK052795 AK076097 AK088519 AK139089 AK154987 AK161356 AK161761 AK163291 AL591440 AY902336 BC031149 CH466596 S72408
GenPept AAB30755 AAH31149 AAX90621 BAC25792 BAC25976 BAC29633 BAC35149 BAC36180 BAC40399 BAE23885 BAE32976 BAE36345 BAE36562 BAE37279 EDL12834 EDL12836
RNA Seq Atlas 12928