Version 5.4
Mus musculus Gene: Abr
Summary
InnateDB Gene IDBG-200937.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abr
Gene Name active BCR-related gene
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000017631
Encoded Proteins
IDBP-200939
active BCR-related gene
IDBP-200941
active BCR-related gene
IDBP-200943
active BCR-related gene
IDBP-264595
active BCR-related gene
IDBP-264597
active BCR-related gene
IDBP-717762
IDBP-718526
IDBP-538680
active BCR-related gene
IDBP-718035
IDBP-717439
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159842:
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:76416734-76622314
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000072740 ENSMUSP00000072522
ENSMUST00000094012 ENSMUSP00000091551
ENSMUST00000065028 ENSMUSP00000068982
ENSMUST00000108408 ENSMUSP00000104045
ENSMUST00000108407 ENSMUSP00000104044
ENSMUST00000131059
ENSMUST00000130364 ENSMUSP00000135174
ENSMUST00000141442
ENSMUST00000151526 ENSMUSP00000135544
ENSMUST00000155035 ENSMUSP00000122614
ENSMUST00000137261
ENSMUST00000176179 ENSMUSP00000135515
ENSMUST00000176024 ENSMUSP00000135691
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0007165 signal transduction
GO:0007420 brain development
GO:0030036 actin cytoskeleton organization
GO:0030336 negative regulation of cell migration
GO:0032319 regulation of Rho GTPase activity
GO:0032496 response to lipopolysaccharide
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042472 inner ear morphogenesis
GO:0043314 negative regulation of neutrophil degranulation
GO:0043547 positive regulation of GTPase activity
GO:0050728 negative regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050885 neuromuscular process controlling balance
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159842
View Gene Order
ENSBTAG00000008424
Not yet available
Pathways
NETPATH
REACTOME
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_209641
NRAGE signals death through JNK pathway
REACT_206918
Signaling by Rho GTPases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_210090
Rho GTPase cycle pathway
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_205369
Signaling by GPCR pathway
REACT_211402
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_211150
Rho GTPase cycle pathway
REACT_214353
Signal Transduction pathway
REACT_209608
Signaling by Rho GTPases pathway
REACT_208369
NRAGE signals death through JNK pathway
REACT_214436
GPCR downstream signaling pathway
REACT_207066
Signalling by NGF pathway
REACT_205384
G alpha (12/13) signalling events pathway
REACT_218183
p75 NTR receptor-mediated signalling pathway
KEGG
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.258939
RefSeq NM_001291186 NM_198018 NM_198894 NM_198895 XM_006531983
OMIM
CCDS CCDS25066 CCDS25067 CCDS36231 CCDS70246
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca