Homo sapiens Gene: POLB
Summary
InnateDB Gene IDBG-20094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLB
Gene Name polymerase (DNA directed), beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000070501
Encoded Proteins
polymerase (DNA directed), beta
polymerase (DNA directed), beta
polymerase (DNA directed), beta
polymerase (DNA directed), beta
polymerase (DNA directed), beta
polymerase (DNA directed), beta
polymerase (DNA directed), beta
polymerase (DNA directed), beta
polymerase (DNA directed), beta
polymerase (DNA directed), beta
polymerase (DNA directed), beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42338454-42371808
Strand Forward strand
Band p11.21
Transcripts
ENST00000265421 ENSP00000265421
ENST00000520008 ENSP00000430610
ENST00000518925 ENSP00000430784
ENST00000519094
ENST00000522297
ENST00000522610 ENSP00000429436
ENST00000519771 ENSP00000427799
ENST00000524208 ENSP00000428578
ENST00000521290 ENSP00000429597
ENST00000519524
ENST00000518579 ENSP00000430478
ENST00000523465
ENST00000517393 ENSP00000428144
ENST00000521492 ENSP00000430831
ENST00000521418
ENST00000532157 ENSP00000432084
ENST00000530566
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016779 nucleotidyltransferase activity
GO:0016829 lyase activity
GO:0019899 enzyme binding
GO:0034061 DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006290 pyrimidine dimer repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008152 metabolic process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045471 response to ethanol
GO:0051402 neuron apoptotic process
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005876 spindle microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
Resolution of Abasic Sites (AP sites) pathway
Removal of DNA patch containing abasic residue pathway
Base Excision Repair pathway
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
Resolution of AP sites via the single-nucleotide replacement pathway pathway
DNA Repair pathway
KEGG
Base excision repair pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.661106
RefSeq NM_002690 XM_005273535 XM_005273537
HUGO
OMIM
CCDS CCDS6129
HPRD 07517
IMGT
EMBL
GenPept
RNA Seq Atlas