Version 5.4
Homo sapiens Gene: POLB
Summary
InnateDB Gene IDBG-20094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLB
Gene Name polymerase (DNA directed), beta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000070501
Encoded Proteins
IDBP-20096
polymerase (DNA directed), beta
IDBP-483078
polymerase (DNA directed), beta
IDBP-476815
polymerase (DNA directed), beta
IDBP-484691
polymerase (DNA directed), beta
IDBP-480578
polymerase (DNA directed), beta
IDBP-477701
polymerase (DNA directed), beta
IDBP-481983
polymerase (DNA directed), beta
IDBP-473877
polymerase (DNA directed), beta
IDBP-485005
polymerase (DNA directed), beta
IDBP-477896
polymerase (DNA directed), beta
IDBP-588891
polymerase (DNA directed), beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been described to date. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:42338454-42371808
Strand Forward strand
Band p11.21
Transcripts
ENST00000265421 ENSP00000265421
ENST00000520008 ENSP00000430610
ENST00000518925 ENSP00000430784
ENST00000519094
ENST00000522297
ENST00000522610 ENSP00000429436
ENST00000519771 ENSP00000427799
ENST00000524208 ENSP00000428578
ENST00000521290 ENSP00000429597
ENST00000519524
ENST00000518579 ENSP00000430478
ENST00000523465
ENST00000517393 ENSP00000428144
ENST00000521492 ENSP00000430831
ENST00000521418
ENST00000532157 ENSP00000432084
ENST00000530566
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 22 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016779 nucleotidyltransferase activity
GO:0016829 lyase activity
GO:0019899 enzyme binding
GO:0034061 DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006290 pyrimidine dimer repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008152 metabolic process
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045471 response to ethanol
GO:0051402 neuron apoptotic process
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005876 spindle microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031536
View Gene Order
ENSBTAG00000000225
Not yet available
Pathways
NETPATH
REACTOME
REACT_1357
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1104
Base Excision Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt P06746
TrEMBL B7Z1W5 E5RHZ4 E5RJ55 Q6LBJ9
UniProt Splice Variant
Entrez Gene 5423
UniGene Hs.661106
RefSeq NM_002690 XM_005273535 XM_005273537
HUGO HGNC:9174
OMIM 174760
CCDS CCDS6129
HPRD 07517
IMGT
EMBL AC083973 AC107885 AF491812 AK294025 AK314976 BC100288 BC106909 CR536503 CR541802 D29013 J04201 L11607 M13140 U10516 U10517 U10519 U10520 U10521 U10522 U10523 U10524 U10525 U10526 X68633
GenPept AAA60133 AAA60134 AAB59441 AAB60688 AAI00289 AAI06910 AAL91594 BAA06099 BAG37475 BAH11651 CAA48603 CAG38741 CAG46601
RNA Seq Atlas 102723810 5423

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca