InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Serpinc1

Summary

InnateDB Gene

IDBG-201299.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinc1

Gene Name

serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

Synonyms

AI114908; At-3; At3; ATIII

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026715

Encoded Proteins

IDBP-201303

serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117601:
The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:160978606-161003010

Strand

Forward strand

Band

H2.1

Transcripts

ENSMUST00000064725

ENSMUSP00000068971

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding

Biological Process

GO:0007584	response to nutrient
GO:0007596	blood coagulation
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0050728	negative regulation of inflammatory response
GO:2000266	regulation of blood coagulation, intrinsic pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000117601

View Gene Order

ENSBTAG00000004362

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_239392

Intrinsic Pathway pathway

REACT_235097

Formation of Fibrin Clot (Clotting Cascade) pathway

REACT_259461

Common Pathway pathway

KEGG

mmu04610

Complement and coagulation cascades pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_326

Intrinsic Pathway pathway

REACT_1439

Common Pathway pathway

REACT_2051

Formation of Fibrin Clot (Clotting Cascade) pathway

REACT_604

Hemostasis pathway

KEGG

hsa04610

Complement and coagulation cascades pathway

INOH

PID NCI

glypican_1pathway

Glypican 1 network

Cross-References

SwissProt

P32261

TrEMBL

Q543J5

UniProt Splice Variant

Entrez Gene

11905

UniGene

Mm.260770

RefSeq

NM_080844 XM_006496626

OMIM

CCDS

CCDS15411

HPRD

IMGT

MGI ID

MGI:88095

MGI Symbol

Serpinc1

EMBL

AB043785 AK050295 BC019447 BC033377 CH466520 S47225

GenPept

AAB23965 AAH19447 AAH33377 BAB16827 BAC34171 EDL39328

RNA Seq Atlas

11905