InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Msh2

Summary

InnateDB Gene

IDBG-201483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msh2

Gene Name

mutS homolog 2 (E. coli)

Synonyms

AI788990

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024151

Encoded Proteins

IDBP-201485

mutS homolog 2 (E. coli)

IDBP-622431

mutS homolog 2 (E. coli)

IDBP-622433

mutS homolog 2 (E. coli)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095002:
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:87672330-87723713

Strand

Forward strand

Band

Transcripts

ENSMUST00000024967	ENSMUSP00000024967
ENSMUST00000174240
ENSMUST00000173097
ENSMUST00000172855	ENSMUSP00000133650
ENSMUST00000172596
ENSMUST00000174703	ENSMUSP00000133488

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0000400	four-way junction DNA binding
GO:0000403	Y-form DNA binding
GO:0000404	heteroduplex DNA loop binding
GO:0000406	double-strand/single-strand DNA junction binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008094	DNA-dependent ATPase activity
GO:0016887	ATPase activity
GO:0019237	centromeric DNA binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0030983	mismatched DNA binding
GO:0032137	guanine/thymine mispair binding
GO:0032138	single base insertion or deletion binding
GO:0032139	dinucleotide insertion or deletion binding
GO:0032142	single guanine insertion binding
GO:0032143	single thymine insertion binding
GO:0032181	dinucleotide repeat insertion binding
GO:0032357	oxidized purine DNA binding
GO:0032405	MutLalpha complex binding
GO:0042803	protein homodimerization activity
GO:0043531	ADP binding

Biological Process

GO:0000710	meiotic mismatch repair
GO:0001701	in utero embryonic development
GO:0002204	somatic recombination of immunoglobulin genes involved in immune response
GO:0006119	oxidative phosphorylation
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006301	postreplication repair
GO:0006302	double-strand break repair
GO:0006311	meiotic gene conversion
GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0007281	germ cell development
GO:0008340	determination of adult lifespan
GO:0008584	male gonad development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010165	response to X-ray
GO:0010224	response to UV-B
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0019724	B cell mediated immunity
GO:0030183	B cell differentiation
GO:0031573	intra-S DNA damage checkpoint
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043524	negative regulation of neuron apoptotic process
GO:0043570	maintenance of DNA repeat elements
GO:0045128	negative regulation of reciprocal meiotic recombination
GO:0045190	isotype switching
GO:0045910	negative regulation of DNA recombination
GO:0051096	positive regulation of helicase activity