Version 5.4
Mus musculus Gene: Prdx6
Summary
InnateDB Gene IDBG-201492.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prdx6
Gene Name peroxiredoxin 6
Synonyms 1-cysPrx; 9430088D19Rik; AA690119; aiPLA2; Aop2; Aop2-rs3; Brp-12; CC26; CP-3; GPx; Ltw-4; Ltw4; Lvtw-4; mKIAA0106; NSGP; NSGPx; ORF06; Prdx5; Prdx6-rs3
Species Mus musculus
Ensembl Gene ENSMUSG00000026701
Encoded Proteins
IDBP-132605
peroxiredoxin 6
IDBP-201494
peroxiredoxin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117592:
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161240112-161251219
Strand Reverse strand
Band H2.1
Transcripts
ENSMUST00000051925 ENSMUSP00000050703
ENSMUST00000071718 ENSMUSP00000071636
ENSMUST00000156678
ENSMUST00000156318
ENSMUST00000139387
ENSMUST00000155135
ENSMUST00000130867
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
GO:0051920 peroxiredoxin activity
Biological Process
GO:0000302 response to reactive oxygen species
GO:0032060 bleb assembly
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117592
View Gene Order
ENSBTAG00000004855
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00360
Phenylalanine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
REACT_206069
Cellular responses to stress pathway
REACT_204534
Detoxification of Reactive Oxygen Species pathway
KEGG
hsa00360
Phenylalanine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q6A0D0 Q6GT24
UniProt Splice Variant
Entrez Gene 11758
UniGene
RefSeq NM_007453 XM_006496624 XM_006544531
OMIM
CCDS CCDS15415
HPRD
IMGT
MGI ID MGI:894320
MGI Symbol Prdx6
EMBL AC115751 AK157820 AK161710 AK172888 BC061181
GenPept AAH61181 BAD32166 BAE34210 BAE36544
RNA Seq Atlas 102642619 11758

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca