Version 5.4
Mus musculus Gene: Tpst1
Summary
InnateDB Gene IDBG-202215.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpst1
Gene Name protein-tyrosine sulfotransferase 1
Synonyms R75054; Tango13a
Species Mus musculus
Ensembl Gene ENSMUSG00000034118
Encoded Proteins
IDBP-202217
protein-tyrosine sulfotransferase 1
IDBP-400216
protein-tyrosine sulfotransferase 1
IDBP-542956
protein-tyrosine sulfotransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21665277
Tpst1 silencing reduces the Il6 production in LPS-stimulated macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 21665277
[Homo sapiens] TPST1 silencing reduces the IL6 production in LPS-stimulated macrophages. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169902:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:130073326-130135729
Strand Forward strand
Band G1.3
Transcripts
ENSMUST00000040721 ENSMUSP00000035614
ENSMUST00000118993 ENSMUSP00000112571
ENSMUST00000142838 ENSMUSP00000119880
ENSMUST00000128335
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0008476 protein-tyrosine sulfotransferase activity
Biological Process
GO:0006478 peptidyl-tyrosine sulfation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000169902
View Gene Order
ENSBTAG00000000390
Not yet available
Cross-References
SwissProt
TrEMBL D3Z1F4
UniProt Splice Variant
Entrez Gene 22021
UniGene Mm.332720
RefSeq NM_001130476 NM_013837
OMIM
CCDS CCDS39293
HPRD
IMGT
MGI ID MGI:1298231
MGI Symbol Tpst1
EMBL AC122339
GenPept
RNA Seq Atlas 22021

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca