InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Sell

Summary

InnateDB Gene

IDBG-202318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sell

Gene Name

selectin, lymphocyte

Synonyms

AI528707; CD62L; L-selectin; LECAM-1; Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026581

Encoded Proteins

IDBP-202320

selectin, lymphocyte

IDBP-202322

selectin, lymphocyte

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000188404:
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:164062076-164080785

Strand

Forward strand

Band

H2.2

Transcripts

ENSMUST00000027871	ENSMUSP00000027871
ENSMUST00000097491	ENSMUSP00000095099

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	4 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007155	cell adhesion
GO:0033198	response to ATP

Cellular Component

GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000188404

View Gene Order

ENSBTAG00000011515

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_202937

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway

REACT_225233

Cell surface interactions at the vascular wall pathway

REACT_230745

Immune System pathway

REACT_229531

Adaptive Immune System pathway

KEGG

mmu04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_11152

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_604

Hemostasis pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q3TCF3

UniProt Splice Variant

Entrez Gene

20343

UniGene

Mm.1461 Mm.403962 Mm.472628

RefSeq

NM_001164059 NM_011346

OMIM

CCDS

CCDS48421 CCDS35753

HPRD

IMGT

MGI ID

MGI:98279

MGI Symbol

Sell

EMBL

AC110499 AK170753

GenPept

BAE42004

RNA Seq Atlas

20343