Version 5.4
Mus musculus Gene: Sarm1
Summary
InnateDB Gene IDBG-202876.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sarm1
Gene Name sterile alpha and HEAT/Armadillo motif containing 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000050132
Encoded Proteins
IDBP-202878
sterile alpha and HEAT/Armadillo motif containing 1
IDBP-264860
sterile alpha and HEAT/Armadillo motif containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23499490
Upon infection with encephalitic Bunyavirus, SARM1 is activated by RIG-I/MAVS signalling to mediate neuronal cell death.
PMID 23751821
Sarm1 is expressed in neurons and regulates the expression of inflammatory and anti-viral cytokines.
PMID 23749635
Sarm1 null mice are resistant to central nervous system infection with vesicular stomatitis virus.
InnateDB Annotation from Orthologs
Summary
PMID 16964262
[Homo sapiens] Negatively regulates adaptor protein TICAM1-dependent Toll-like receptor signaling
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004139:
Gene Information
Type Protein coding
Genomic Location Chromosome 11:78472330-78497754
Strand Reverse strand
Band B5
Transcripts
ENSMUST00000061174 ENSMUSP00000051059
ENSMUST00000108287 ENSMUSP00000103922
ENSMUST00000153534
ENSMUST00000130955
ENSMUST00000170674
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0009749 response to glucose
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048814 regulation of dendrite morphogenesis
GO:1901214 regulation of neuron death
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0031315 extrinsic component of mitochondrial outer membrane
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000004139
View Gene Order
ENSBTAG00000002816
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.210332
RefSeq NM_001168521 NM_172795 XM_006533231
OMIM
CCDS CCDS25105 CCDS48857
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca