Mus musculus Gene: Rfc2
Summary
InnateDB Gene IDBG-202915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rfc2
Gene Name replication factor C (activator 1) 2
Synonyms 2610008M13Rik; 40kDa; AI326953; Recc2;
Species Mus musculus
Ensembl Gene ENSMUSG00000023104
Encoded Proteins
replication factor C (activator 1) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049541:
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134582690-134598328
Strand Forward strand
Band G2
Transcripts
ENSMUST00000023867 ENSMUSP00000023867
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006260 DNA replication
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transcription-coupled NER (TC-NER) pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Chromosome Maintenance pathway
Synthesis of DNA pathway
DNA strand elongation pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA Replication pathway
Global Genomic NER (GG-NER) pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Telomere Maintenance pathway
Cell Cycle pathway
Nucleotide Excision Repair pathway
Cell Cycle Checkpoints pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
DNA Repair pathway
Leading Strand Synthesis pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
G2/M Checkpoints pathway
Extension of Telomeres pathway
Polymerase switching pathway
Activation of ATR in response to replication stress pathway
Lagging Strand Synthesis pathway
Polymerase switching on the C-strand of the telomere pathway
S Phase pathway
KEGG
DNA replication pathway
Nucleotide excision repair pathway
Mismatch repair pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DNA Replication pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
Polymerase switching on the C-strand of the telomere pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Transcription-coupled NER (TC-NER) pathway
Synthesis of DNA pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
S Phase pathway
Chromosome Maintenance pathway
Polymerase switching pathway
G2/M Checkpoints pathway
Global Genomic NER (GG-NER) pathway
Telomere Maintenance pathway
Cell Cycle pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Leading Strand Synthesis pathway
Extension of Telomeres pathway
Lagging Strand Synthesis pathway
Nucleotide Excision Repair pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
DNA Repair pathway
Cell Cycle Checkpoints pathway
S Phase pathway
Gap-filling DNA repair synthesis and ligation in TC-NER pathway
Extension of Telomeres pathway
Transcription-coupled NER (TC-NER) pathway
DNA Replication pathway
Telomere Maintenance pathway
Polymerase switching on the C-strand of the telomere pathway
Leading Strand Synthesis pathway
Nucleotide Excision Repair pathway
Cell Cycle, Mitotic pathway
Gap-filling DNA repair synthesis and ligation in GG-NER pathway
Global Genomic NER (GG-NER) pathway
Telomere C-strand (Lagging Strand) Synthesis pathway
Synthesis of DNA pathway
Cell Cycle pathway
DNA Repair pathway
Lagging Strand Synthesis pathway
Chromosome Maintenance pathway
G2/M Checkpoints pathway
Activation of ATR in response to replication stress pathway
Polymerase switching pathway
Repair synthesis of patch ~27-30 bases long by DNA polymerase pathway
Cell Cycle Checkpoints pathway
Repair synthesis for gap-filling by DNA polymerase in TC-NER pathway
DNA strand elongation pathway
KEGG
DNA replication pathway
Nucleotide excision repair pathway
Mismatch repair pathway
INOH
PID BIOCARTA
PID NCI
Fanconi anemia pathway
ATR signaling pathway
Cross-References
SwissProt Q9WUK4
TrEMBL Q4KL82 Q99K91
UniProt Splice Variant
Entrez Gene 19718
UniGene Mm.332739 Mm.409955 Mm.447557
RefSeq NM_020022
OMIM
CCDS CCDS19722
HPRD
IMGT
MGI ID MGI:1341868
MGI Symbol Rfc2
EMBL AF139987 AF289664 AK075997 AK154681 BC004812 BC023028 BC099370 CH466529
GenPept AAD34861 AAF99332 AAH04812 AAH23028 AAH99370 BAC36108 BAE32762 EDL19423
RNA Seq Atlas 19718