Mus musculus Gene: Eif4h
Summary
InnateDB Gene IDBG-203011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4h
Gene Name eukaryotic translation initiation factor 4H
Synonyms AU018978; D5Ertd355e; E430026L18Rik; Ef4h; mKIAA0038; Wbscr1; Wscr1;
Species Mus musculus
Ensembl Gene ENSMUSG00000040731
Encoded Proteins
eukaryotic translation initiation factor 4H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106682:
This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:134619880-134639348
Strand Reverse strand
Band G2
Transcripts
ENSMUST00000036125 ENSMUSP00000048833
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006413 translational initiation
GO:0019953 sexual reproduction
GO:0048589 developmental growth
Cellular Component
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Initiation pathway
Gene Expression pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Eukaryotic Translation Initiation pathway
Cap-dependent Translation Initiation pathway
Translation pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Metabolism of proteins pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation initiation complex formation pathway
Ribosomal scanning and start codon recognition pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9WUK2
TrEMBL Q3TG58 Q564E5 Q9ET00
UniProt Splice Variant
Entrez Gene 22384
UniGene Mm.428932
RefSeq NM_033561
OMIM
CCDS CCDS19723
HPRD
IMGT
MGI ID MGI:1341822
MGI Symbol Eif4h
EMBL AF139987 AF289664 AF289665 AK045004 AK088818 AK135390 AK136999 AK149841 AK150088 AK166567 AK168872 AK169312 AK169353 AK169407 BC014796 CH466529
GenPept AAD34859 AAD34860 AAF99330 AAF99335 AAH14796 BAC32180 BAC40593 BAE22517 BAE23201 BAE29116 BAE29297 BAE38858 BAE40690 BAE41067 BAE41102 BAE41153 EDL19418 EDL19419
RNA Seq Atlas 22384