InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Eln

Summary

InnateDB Gene

IDBG-203188.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eln

Gene Name

elastin

Synonyms

AI385707; AI480567; E030024M20Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029675

Encoded Proteins

IDBP-203190

elastin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049540:
This gene encodes a protein that is one of the two components of elastic fibers. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:134703781-134747241

Strand

Reverse strand

Band

Transcripts

ENSMUST00000015138

ENSMUSP00000015138

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030023	extracellular matrix constituent conferring elasticity
GO:0050840	extracellular matrix binding

Biological Process

GO:0001974	blood vessel remodeling
GO:0007519	skeletal muscle tissue development
GO:0030198	extracellular matrix organization
GO:0030833	regulation of actin filament polymerization
GO:0043149	stress fiber assembly