InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ccr4

Summary

InnateDB Gene

IDBG-203512.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccr4

Gene Name

chemokine (C-C motif) receptor 4

Synonyms

C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r

Species

Mus musculus

Ensembl Gene

ENSMUSG00000047898

Encoded Proteins

IDBP-203514

chemokine (C-C motif) receptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18624303

[Homo sapiens] CCR4 modulates TLR9-mediated innate immunity and signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183813:
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:114490316-114496544

Strand

Reverse strand

Band

Transcripts

ENSMUST00000054414

ENSMUSP00000062677

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0016493	C-C chemokine receptor activity

Biological Process

GO:0001764	neuron migration
GO:0002507	tolerance induction
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0009314	response to radiation
GO:0009617	response to bacterium
GO:0046677	response to antibiotic
GO:0050927	positive regulation of positive chemotaxis
GO:0070098	chemokine-mediated signaling pathway