Mus musculus Gene: Ccr4
Summary
InnateDB Gene IDBG-203512.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccr4
Gene Name chemokine (C-C motif) receptor 4
Synonyms C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r;
Species Mus musculus
Ensembl Gene ENSMUSG00000047898
Encoded Proteins
chemokine (C-C motif) receptor 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] CCR4 modulates TLR9-mediated innate immunity and signalling.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183813:
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:114490316-114496544
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000054414 ENSMUSP00000062677
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0016493 C-C chemokine receptor activity
Biological Process
GO:0001764 neuron migration
GO:0002507 tolerance induction
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0009314 response to radiation
GO:0009617 response to bacterium
GO:0046677 response to antibiotic
GO:0050927 positive regulation of positive chemotaxis
GO:0070098 chemokine-mediated signaling pathway
Cellular Component
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
G alpha (i) signalling events pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Chemokine receptors bind chemokines pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Chemokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P51680
TrEMBL
UniProt Splice Variant
Entrez Gene 12773
UniGene Mm.1337
RefSeq NM_009916 XM_006511933 XM_006511934
OMIM
CCDS CCDS23594
HPRD
IMGT
MGI ID MGI:107824
MGI Symbol Ccr4
EMBL BC117041 BC119171 CH466587 U15208 X90862
GenPept AAA92582 AAI17042 AAI19172 CAA62372 EDL09307 EDL09308
RNA Seq Atlas 12773